Role of N-Ras in murine models of liver fibrosis
- Zheng, Kang
- Edgar Fernández Malavé Director
- Francisco Javier Cubero Palero Director
Defence university: Universidad Complutense de Madrid
Fecha de defensa: 19 July 2021
- José Manuel Martín Villa Chair
- Ana Victoria Marín Marín Secretary
- Matthias Bartneck Committee member
- Ana Blas García Committee member
- Francisco Javier Vaquero Martin Committee member
Type: Thesis
Abstract
The Ras genes (H-Ras, K-Ras and N-Ras) encode for the RAS proteins with pivotal roles in the regulation of cell survival, differentiation, growth and apoptosis. Apart from their oncogenic properties, little is known on the context and cell-dependent pathophysiological roles of RAS proteins. In particular, N-RAS is critically involved in immune cell function. Hepatic fibrogenesis develops in response to inflammatory cytokines, cellular interactions with immune cells and morphogenic signals. In the present work, we hypothesized that N-Ras plays a pivotal role in the pathophysiology of liver fibrogenesis...