Role of N-Ras in murine models of liver fibrosis
- Zheng, Kang
- Edgar Fernández Malavé Doktorvater/Doktormutter
- Francisco Javier Cubero Palero Doktorvater/Doktormutter
Universität der Verteidigung: Universidad Complutense de Madrid
Fecha de defensa: 19 von Juli von 2021
- José Manuel Martín Villa Präsident/in
- Ana Victoria Marín Marín Sekretär/in
- Matthias Bartneck Vocal
- Ana Blas García Vocal
- Francisco Javier Vaquero Martin Vocal
Art: Dissertation
Zusammenfassung
The Ras genes (H-Ras, K-Ras and N-Ras) encode for the RAS proteins with pivotal roles in the regulation of cell survival, differentiation, growth and apoptosis. Apart from their oncogenic properties, little is known on the context and cell-dependent pathophysiological roles of RAS proteins. In particular, N-RAS is critically involved in immune cell function. Hepatic fibrogenesis develops in response to inflammatory cytokines, cellular interactions with immune cells and morphogenic signals. In the present work, we hypothesized that N-Ras plays a pivotal role in the pathophysiology of liver fibrogenesis...