Riesgo cardiovascular y cirugía bariátrica en pacientes con alteración del metabolismo hidrocarbonado

Laburpena

The doctoral thesis is a compendium of three scientific publications. The main objective was to establish whether patients with morbid obesity and pre-diabetes would present a similar cardiovascular risk reduction to patients with T2DM after undergoing bariatric surgery. In addition, a review of pharmacological and surgical treatment has been carried out in obesity and T2DM. Finally, a meta-analysis was performed to assess whether metabolic surgery was effective in the remission of T2DM in patients with BMI <30 kg/m2. It was observed that patients with T2DM are those who reduce their cardiovascular risk the most 12 months after surgery, although patients with pre-diabetes also experience an improvement. Currently, new drugs are available for treatment of obesity and T2DM that improve cardiovascular risk, in addition to surgery. Metabolic surgery may be effective in patients with T2DM without obesity, although more long-term studies are necessary.