Publicacions en col·laboració amb investigadors/es de King Saud University (13)

2024

  1. Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules

    Frontiers in Pharmacology, Vol. 15

  2. MEDT analysis of mechanism and selectivities in non-catalyzed and lewis acid-catalyzed diels–alder reactions between R-carvone and isoprene

    Scientific Reports, Vol. 14, Núm. 1

2023

  1. A MEDT study of the mechanism and selectivity of the hetero-Diels–Alder reaction between 3-benzoylpyrrolo[1,2-c][1,4]-benzoxazine-1,2,4-trione and vinyl acetate

    Chemistry of Heterocyclic Compounds, Vol. 59, Núm. 3, pp. 165-170

  2. A novel alpha-amylase inhibitor-based spirooxindole-pyrrolidine-clubbed thiochromene-pyrzaole pharmacophores: Unveiling the [3+2] cycloaddition reaction by molecular electron density theory

    Chemical Biology and Drug Design, Vol. 102, Núm. 5, pp. 972-995

  3. New spiro-indeno[1,2-b]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insights

    Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 38, Núm. 1

  4. Synthesis and anti-Cancer Activity of a New Hybrid Based Spirooxindole-Pyrrolidine -Thiochromene Scaffolds via [3 + 2] Cycloaddition Reaction: Computational Investigation

    Polycyclic Aromatic Compounds, Vol. 43, Núm. 3, pp. 2302-2320

  5. Synthesis, In Vitro and in Cell Study of a New Spirooxindoles-Based N-Alkylated Maleimides Targeting HER2/3 Signaling Pathway

    Polycyclic Aromatic Compounds, Vol. 43, Núm. 6, pp. 5251-5275

2022

  1. A Molecular Electron Density Theory Study of the [3+2] Cycloaddition Reaction of an Azomethine Ylide with an Electrophilic Ethylene Linked to Triazole and Ferrocene Units

    Molecules, Vol. 27, Núm. 19

  2. Design, Synthesis and In Vitro Evaluation of Spirooxindole-Based Phenylsulfonyl Moiety as a Candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of Combination Studies

    International Journal of Molecular Sciences, Vol. 23, Núm. 19

  3. [3 + 2] Cycloadditions in Asymmetric Synthesis of Spirooxindole Hybrids Linked to Triazole and Ferrocene Units: X-ray Crystal Structure and MEDT Study of the Reaction Mechanism

    Symmetry, Vol. 14, Núm. 10

2021

  1. Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation

    Frontiers in Chemistry, Vol. 9

  2. Straightforward regio- and diastereoselective synthesis, molecular structure, intermolecular interactions and mechanistic study of spirooxindole-engrafted rhodanine analogs

    Molecules, Vol. 26, Núm. 23

  3. Synthesis of Spirooxindole Analogs Tethered Pyrazole Scaffold as Acetylcholinesterase Inhibitors

    ChemistrySelect, Vol. 6, Núm. 48, pp. 14039-14053