Publicaciones en colaboración con investigadores/as de Cardiff University (9)

2019

  1. Heavy Enzymes and the Rational Redesign of Protein Catalysts

    ChemBioChem, Vol. 20, Núm. 22, pp. 2807-2812

  2. Loss of Hyperconjugative Effects Drives Hydride Transfer during Dihydrofolate Reductase Catalysis

    ACS Catalysis, Vol. 9, Núm. 11, pp. 10343-10349

  3. Why are some enzymes dimers? Flexibility and catalysis in thermotoga maritima dihydrofolate reductase

    ACS Catalysis, Vol. 9, Núm. 7, pp. 5902-5911

2018

  1. Isotope Substitution of Promiscuous Alcohol Dehydrogenase Reveals the Origin of Substrate Preference in the Transition State

    Angewandte Chemie - International Edition, Vol. 57, Núm. 12, pp. 3128-3131

2016

  1. Minimization of dynamic effects in the evolution of dihydrofolate reductase

    Chemical Science, Vol. 7, Núm. 5, pp. 3248-3255

2015

  1. Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase

    Angewandte Chemie - International Edition, Vol. 54, Núm. 31, pp. 9016-9020

2014

  1. Protein isotope effects in dihydrofolate reductase from geobacillus stearothermophilus show entropic-enthalpic compensatory effects on the rate constant

    Journal of the American Chemical Society, Vol. 136, Núm. 49, pp. 17317-17323

2013

  1. Increased dynamic effects in a catalytically compromised variant of escherichia coli dihydrofolate reductase

    Journal of the American Chemical Society, Vol. 135, Núm. 49, pp. 18689-18696

  2. Unraveling the role of protein dynamics in dihydrofolate reductase catalysis

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Núm. 41, pp. 16344-16349