Análisis de los factores de riesgo para el progreso y la regresión de la enfermedad de hígado graso no alcohólicaAspectos cualitativos de la dieta, alcohol y actividad física

Resumen

Non-alcoholic fatty liver disease (NAFLD), which ranges from simple fatty liver, through non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis, is present in more than 20% of the general population. The high prevalence of NAFLD is probably due to the contemporary epidemics of obesity, unhealthy dietary pattern, and sedentary lifestyle. The cornerstone of any treatment regimen for patients with NAFLD is lifestyle modification focused on dietary changes and physical activity. The main objective of our study was to outline the effect of diet and lifestyle factors on the development of NAFLD. First, we aim to test whether qualitative aspects of diet suchas levels of Palmitic acid (PA) and the fat source, are risk factors for NAFLD. Second, we used a synergistic DUAL murine model of NAFLD and alcohol consumption to study the biological impact of physical exercise and dietary changes on the regression of steatohepatitis and fibrosis. Finally, we confirmed our finding in an alternative animal model, zebrafish (Danio rerio)...