Looking again, and harder, for a link between molecules and severe mental disorders: A translational and integrated multi-disciplinary approach

  1. Tabarés Seisdedos, Rafael 1
  2. Balanzá Martínez, Vicente 1
  3. Escámez Martínez, T. 3
  4. Etxevarría Aza, D. 23
  5. Selva-Vera, G. l. 1
  6. Salazar Fraile, José 45
  7. Fuentes Durá, Inmaculada 6
  8. Correa Ghysais, P.
  9. Gómez Beneyto, Manuel 1
  10. Ponce, B.
  11. Geijo-Barrientos, E.
  12. Martínez Pérez, S.
  1. 1 Universitat de València
    info

    Universitat de València

    Valencia, España

    ROR https://ror.org/043nxc105

  2. 2 Instituto de Neurociencias de Alicante. Universidad Miguel Hernández, Alicante
  3. 3 Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
  4. 4 Hospital General Universitario de Valencia
    info

    Hospital General Universitario de Valencia

    Valencia, España

    ROR https://ror.org/03sz8rb35

  5. 5 Centro de Investigacion Biomedica en Red de Salud Mental
    info

    Centro de Investigacion Biomedica en Red de Salud Mental

    Madrid, España

    ROR https://ror.org/009byq155

  6. 6 Universitat de València (2011)
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Revista:
European Journal of Psychiatry

ISSN: 0213-6163

Año de publicación: 2009

Volumen: 23

Páginas: 160-166

Tipo: Artículo

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Otras publicaciones en: European Journal of Psychiatry

Resumen

The last decade has witnessed a growing interest to evaluate the aetiologyof schizophrenia and bipolar disorders through a genetic, molecular and cellular analysis,as well as to assess the influence of epigenetic factors in the phenotypic presentation ofthese severe disorders. We have used the following methods: We analysed six lines of research: The Valencia Follow-Up Study of Schizophrenia and Bipolar I Disorders, TheNeurocognitive Endophenotype (Endophenocognitype) Study, The Negative ComorbidityStudy, Experimental Embryology, Neurogenetics, and Clinical Genetics. We have described a translational and integrated multi-disciplinary approach to set a framework aimed toidentify molecular mechanisms and valid endophenotypes for schizophrenia and bipolar disorders. Conclusions: The University of Valencia and the Alicante Neuroscience Institute(UVANI) - CIBERSAM node is a specialized resource providing basic topics, clinical care, education and research in the area of severe mental disorders.

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Información de financiación

This study was supported by grants from the following: Spanish ETES-MSI Grant PI0890416 (RTS); Spanish FIS-MSI Grant PI081024 (VBM), the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III, CIBERSAM and Fundación Alicia Koplowitz to RTS.