Asociación de la placa de ateroma carotídea con los niveles plasmáticos de IL-18 y con polimorfismos en el gen del receptor de la IL-18 en la población mediterránea

  1. Ana Palanca 1
  2. Amparo Bartual-Rodrigo 2
  3. Carolina Cuenca 3
  4. Oscar D. Mayo-López 3
  5. Francisco Javier Ampudia-Blasco 4
  6. Herminia González-Navarro 5
  7. Juan F. Ascaso 6
  8. Ana Bárbara García-García 7
  9. Felipe Javier Chaves 7
  10. José T. Real 4
  11. Sergio Martínez-Hervás 4
  1. 1 Hospital Clínico Universitario de Valencia, Valencia, España; Instituto de Investigación Sanitaria, Valencia, España
  2. 2 Hospital Clínico Universitario de Valencia, Valencia, España
  3. 3 Instituto de Investigación Sanitaria, Valencia, España
  4. 4 Hospital Clínico Universitario de Valencia, Valencia, España; Instituto de Investigación Sanitaria, Valencia, España; Instituto de Salud Carlos III, Madrid, España; Universitat de València, Valencia, España
  5. 5 Instituto de Investigación Sanitaria, Valencia, España; Universitat de València, Valencia, España; Instituto de Salud Carlos III, Madrid, España
  6. 6 Instituto de Investigación Sanitaria, Valencia, España; Universitat de València, Valencia, España
  7. 7 Instituto de Investigación Sanitaria, Valencia, España; Instituto de Salud Carlos III, Madrid, España; Instituto de Investigación Sanitaria, Valencia, España
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Revista:
Clínica e investigación en arteriosclerosis

ISSN: 0214-9168,  1578-1879

Any de publicació: 2024

Volum: 36

Número: 4

Pàgines: 210-217

Tipus: Article

DOI: 10.1016/J.ARTERI.2023.12.005 DIALNET GOOGLE SCHOLAR lock_openAccés obert editor

Altres publicacions en: Clínica e investigación en arteriosclerosis

Resum

Background: Atherosclerosis is an inflammatory disease. Interleukin 18 (IL-18) is an inflammatory molecule that has been linked to the development of atherosclerosis and cardiovascular disease. Objective: To evaluate the possible relationship between plasma levels of IL-18 and the presence of atherosclerosis evaluated at the carotid level, as well as to analyze the possible modulation by different polymorphisms in a Mediterranean population. Material and methods: Seven hundred and forty-six individuals from the metropolitan area of Valencia were included, recruited over a period of 2 years. Hydrocarbon and lipid metabolism parameters were determined using standard methodology and IL-18 using ELISA. In addition, carotid ultrasound was performed and the genotype of four SNPs related to the IL-18 signaling pathway was analyzed. Results: Patients with higher plasma levels of IL-18 had other associated cardiovascular risk factors. Elevated IL-18 levels were significantly associated with higher carotid IMT and the presence of atheromatous plaques. The genotype with the A allele of the SNP rs2287037 was associated with a higher prevalence of carotid atheromatous plaque. On the contrary, the genotype with the C allele of the SNP rs2293224 was associated with a lower prevalence of atheromatous plaque. Conclusions: High levels of IL-18 were significantly associated with a higher carotid IMT and the presence of atheromatous plaques, which appear to be influenced by genetic factors, as evidenced by associations between SNPs in the IL-18 receptor gene and the presence of atheroma plaque.

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