Effects of oral capsaicinoids and capsinoids supplementation on resistance and high intensity interval trainingA systematic review of randomized controlled trials

  1. Pablo Jiménez Martínez 1
  2. Rodrigo Ramírez Campillo 2
  3. Jorge Flandez 3
  4. Carlos Alix Fages 4
  5. Eneko Baz 5
  6. Juan Carlos Colado Sánchez 1
  1. 1 Universitat de València
    info

    Universitat de València

    Valencia, España

    ROR https://ror.org/043nxc105

  2. 2 University Andres Bello
  3. 3 Universidad Austral de Chile
    info

    Universidad Austral de Chile

    Valdivia, Chile

    ROR https://ror.org/029ycp228

  4. 4 Universidad Autónoma de Madrid
    info

    Universidad Autónoma de Madrid

    Madrid, España

    ROR https://ror.org/01cby8j38

  5. 5 University of País Vasco
Mostrar afiliaciones +
Revista:
Journal of Human Sport and Exercise: JHSE

ISSN: 1988-5202

Año de publicación: 2023

Volumen: 18

Número: 2

Páginas: 375-389

Tipo: Artículo

DOI: 10.14198/JHSE.2023.182.09 DIALNET GOOGLE SCHOLAR lock_openRUA editor

Otras publicaciones en: Journal of Human Sport and Exercise: JHSE

Objetivos de desarrollo sostenible

Resumen

Oral capsaicinoids and capsinoids supplementation has been studied recently for a plausible ergogenic impact on sports performance. However, non-aggregated literature has focused on the impact of this substances in healthy humans’ performance. The aim of the present systematic review was to explore the effects of capsaicinoids and capsinoids on resistance training (RT) and HIIT exercise. Studies searches were performed in the PubMed/MEDLINE, Scopus and Web of Science electronic databases. Studies where healthy subjects consumed capsaicinoids or capsinoids acutely or chronically compared to placebo before a RT or HIIT intervention were included. The methodological quality of the included studies was assessed with PEDro checklist. A total of 7 excellent-good quality placebo-controlled trials (i.e., 5 RT and 2 HIIT experiments) were included. The most prevalent protocol used capsaicin (i.e., 6 capsacin and 1 capsiate studies) and acute (i.e., 5 of 7 interventions) supplementation designs. Positive effects were only noted for capsaicin in repetitions until failure (+14.4 to +21.7%), total weight lifted (+13.0 to +23.3%), perceived effort (-6.4%), fatigue index (+15.0%) and peak torque (+6.1%) compared to placebo. Neuromuscular HIIT variables (e.g., total and medium sprint time) were not highly affected by capsaicin except the time to reach 90% VO2 peak (+61.2%) and the number of efforts performed (+14.7%). Collectively, our findings suggest a positive effect of 12 mg of capsaicin on strength endurance, total weight lifted and perceived effort variables in healthy males after acute (i.e., 45 minutes pre-exercise) supplementation.

Referencias bibliográficas

  • Alali, M., Alqubaisy, M., Aljaafari, M. N., Alali, A. O., Baqais, L., Molouki, A., Abushelaibi, A., Lai, K. S., & Lim, S. H. E. (2021). Nutraceuticals: Transformation of conventional foods into health promoters/disease preventers and safety considerations. Molecules, 26(9). https://doi.org/10.3390/molecules26092540
  • Amann, M., Blain, G. M., Proctor, L. T., Sebranek, J. J., Pegelow, D. F., & Dempsey, J. A. (2010). Group III and IV muscle afferents contribute to ventilatory and cardiovascular response to rhythmic exercise in humans. Journal of Applied Physiology (Bethesda, Md. : 1985), 109(4), 966-976. https://doi.org/10.1152/japplphysiol.00462.2010
  • Baamonde, A., Lastra, A., Juarez, L., Hidalgo, A., & Menéndez, L. (2005). TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues. Brain Research Bulletin, 67(6), 476-481. https://doi.org/10.1016/j.brainresbull.2005.07.001
  • Basith, S., Cui, M., Hong, S., & Choi, S. (2016). Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases. Molecules, 21(8). https://doi.org/10.3390/molecules21080966
  • Chrubasik, S., Weiser, T., & Beime, B. (2010). Effectiveness and safety of topical capsaicin cream in the treatment of chronic soft tissue pain. Phytotherapy Research, 24(12), 1877-1885. https://doi.org/10.1002/ptr.3335
  • Collins, B. W., Pearcey, G. E. P., Buckle, N. C. M., Power, K. E., & Button, D. C. (2018). Neuromuscular fatigue during repeated sprint exercise: underlying physiology and methodological considerations. Applied Physiology, Nutrition, and Metabolism, 43(11), 1166-1175. https://doi.org/10.1139/apnm-2018-0080
  • Cross, B. L., Parker, D., Langan, S. P., & Grosicki, G. J. (2020). Effect of a commercially available low-dose capsaicin supplement on knee extensor contractile function. International Journal of Exercise Science, 13(2), 312-318.
  • de Freitas, M. C., Billaut, F., Panissa, V. L. G., Rossi, F. E., Figueiredo, C., Caperuto, E. C., & Lira, F. S. (2019a). Capsaicin supplementation increases time to exhaustion in high-intensity intermittent exercise without modifying metabolic responses in physically active men. European Journal of Applied Physiology, 119(4), 971-979. https://doi.org/10.1007/s00421-019-04086-w
  • de Freitas, M. C., Cholewa, J. M., Freire, R. V., Carmo, B. A., Bottan, J., Bratfich, M., della Bandeira, M. P., Gonçalves, D. C., Caperuto, E. C., Lira, F. S., Lira, F. S., & Rossi, F. E. (2018). Acute capsaicin supplementation improves resistance training performance in trained men. Journal of Strength and Conditioning Research, 32(8), 2227-2232. https://doi.org/10.1519/jsc.0000000000002109
  • de Freitas, M. C., Cholewa, J. M., Panissa, V. L. G., Toloi, G. G., Netto, H. C., Zanini de Freitas, C., Freire, R. V., Lira, F. S., & Rossi, F. E. (2019). Acute Capsaicin Supplementation Improved Resistance Exercise Performance Performed After a High-Intensity Intermittent Running in Resistance-Trained Men. Journal of Strength and Conditioning Research, Publish Ah, 6-10. https://doi.org/10.1519/jsc.0000000000003431
  • de Moura e Silva, V. E. L., Cholewa, J. M., Billaut, F., Jäger, R., de Freitas, M. C., Lira, F. S., & Rossi, F. E. (2021a). Capsaicinoid and capsinoids as an ergogenic aid: A systematic review and the potential mechanisms involved. International Journal of Sports Physiology and Performance, 16(4), 464-473. https://doi.org/10.1123/IJSPP.2020-0677
  • de Moura e Silva, V. E. L., Cholewa, J. M., Jäger, R., Zanchi, N. E., de Freitas, M. C., de Moura, R. C., Barros, E. M. L., Antunes, B. M., Caperuto, E. C., Ribeiro, S. L. G., Lira, F. S., Pereira dos Santos, M. A., & Rossi, F. E. (2021). Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: a randomized, placebo-controlled and double-blind study. Journal of the International Society of Sports Nutrition, 18(1), 1-9. https://doi.org/10.1186/s12970-021-00446-0
  • Drevon, D., Fursa, S. R., & Malcolm, A. L. (2017). Intercoder Reliability and Validity of WebPlotDigitizer in Extracting Graphed Data. Behavior Modification, 41(2), 323-339. https://doi.org/10.1177/0145445516673998
  • Foley, N. C., Bhogal, S. K., Teasell, R. W., Bureau, Y., & Speechley, M. R. (2006). Database Scale to Assess the Methodology of Randomized Controlled Trials of. Physical Therapy, 86(6), 817-824. https://doi.org/10.1093/ptj/86.6.817
  • Froyd, C., Millet, G. Y., & Noakes, T. D. (2013). The development of peripheral fatigue and short-term recovery during self-paced high-intensity exercise. Journal of Physiology, 591(5), 1339-1346. https://doi.org/10.1113/jphysiol.2012.245316
  • Hayman, M., & Kam, P. C. A. (2008). Capsaicin: A review of its pharmacology and clinical applications. Current Anaesthesia and Critical Care, 19(5-6), 338-343. https://doi.org/10.1016/j.cacc.2008.07.003
  • Ito, N., Ruegg, U. T., Kudo, A., Miyagoe-Suzuki, Y., & Takeda, S. (2013). Capsaicin mimics mechanical load-induced intracellular signaling events: Involvement of TRPV1-mediated calcium signaling in induction of skeletal muscle hypertrophy. Channels, 7(3), 221-224. https://doi.org/10.4161/chan.24583
  • Jes, A., Paola, L., Tobal, F. M., Jodra, P., Jos, J., Guerra-hern, E. J., Jos, J., & Ramos-, Á. (2021). Professional Rugby Players. 1-15.
  • Kamiński, M., Kręgielska-Narożna, M., & Bogdański, P. (2020). Determination of the popularity of dietary supplements using google search rankings. Nutrients, 12(4). https://doi.org/10.3390/nu12040908
  • Kaufman, M. P., Iwamoto, G. A., Longhurst, J. C., & Mitchell, J. H. (1982). Effects of capsaicin and bradykinin on afferent fibers with ending in skeletal muscle. Circulation Research, 50(1), 133-139. https://doi.org/10.1161/01.RES.50.1.133
  • Knapik, J. J., Steelman, R. A., Hoedebecke, S. S., Austin, K. G., Farina, E. K., & Lieberman, H. R. (2016). Prevalence of Dietary Supplement Use by Athletes: Systematic Review and Meta-Analysis. Sports Medicine, 46(1), 103-123. https://doi.org/10.1007/s40279-015-0387-7
  • Knotkova, H., Pappagallo, M., & Szallasi, A. (2008). Capsaicin (TRPV1 agonist) therapy for pain relief: Farewell or revival? Clinical Journal of Pain, 24(2), 142-154. https://doi.org/10.1097/AJP.0b013e318158ed9e
  • Lang, Y., Kisaka, H., Sugiyama, R., Nomura, K., Morita, A., Watanabe, T., Tanaka, Y., Yazawa, S., & Miwa, T. (2009). Functional loss of pAMT results in biosynthesis of capsinoids, capsaicinoid analogs, in capsicum annuum cv. CH-19 sweet. Plant Journal, 59(6), 953-961. https://doi.org/10.1111/j.1365-313X.2009.03921.x
  • Lebovitz, E. E., Keller, J. M., Kominsky, H., Kaszas, K., Maric, D., & Iadarola, M. J. (2012). Positive allosteric modulation of TRPV1 as a novel analgesic mechanism. Molecular Pain, 8, 1-14. https://doi.org/10.1186/1744-8069-8-70
  • Luo, X. J., Peng, J., & Li, Y. J. (2011). Recent advances in the study on capsaicinoids and capsinoids. European Journal of Pharmacology, 650(1), 1-7. https://doi.org/10.1016/j.ejphar.2010.09.074
  • Maher, C. G., Sherrington, C., Herbert, R. D., Moseley, A. M., & Elkins, M. (2003). Reliability of the PEDro scale for rating quality of randomized controlled trials. Physical Therapy, 83(8), 713-721. https://doi.org/10.1093/ptj/83.8.713
  • Mahmmoud, Y. A. (2008). Capsaicin stimulates uncoupled ATP hydrolysis by the sarcoplasmic reticulum calcium pump. Journal of Biological Chemistry, 283(31), 21418-21426. https://doi.org/10.1074/jbc.M803654200
  • Mannozzi, J., Al-Hassan, M. H., Lessanework, B., Alvarez, A., Senador, D., & O'Leary, D. S. (2021). Chronic ablation of TRPV1-sensitive skeletal muscle afferents attenuates the muscle metaboreflex. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 321(3), R385-R395. https://doi.org/10.1152/ajpregu.00129.2021
  • Márquez, G., Romero-Arenas, S., Marín-Pagán, C., Vera-Ibañez, A., FernáNdez Del Olmo, M., & Taube, W. (2017). Peripheral and central fatigue after high intensity resistance circuit training. Muscle and Nerve, 56(1), 152-159. https://doi.org/10.1002/mus.25460
  • Mason, L., Moore, R. A., Derry, S., Edwards, J. E., & McQuay, H. J. (2004). Systematic review of topical capsaicin for the treatment of chronic pain. British Medical Journal, 328(7446), 991-994. https://doi.org/10.1136/bmj.38042.506748.ee
  • Mata, F., Domínguez, R., López-Samanes, Á., Sánchez-Gómez, Á., Jodra, P., & Sánchez-Oliver, A. J. (2021). Analysis of the consumption of sports supplements in elite fencers according to sex and competitive level. BMC Sports Science, Medicine and Rehabilitation, 13(1), 1-9. https://doi.org/10.1186/s13102-021-00278-0
  • Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., Meeusen, R., van Loon, L. J. C., Shirreffs, S. M., Spriet, L. L., Stuart, M., Vernec, A., Currell, K., Ali, V. M., Budgett, R. G., … Engebretsen, L. (2018). IOC consensus statement: Dietary supplements and the high-performance athlete. British Journal of Sports Medicine, 52(7), 439-455. https://doi.org/10.1136/bjsports-2018-099027
  • Moseley, A. M., Rahman, P., Wells, G. A., Zadro, J. R., Sherrington, C., Toupin-April, K., & Brosseau, L. (2019). Agreement between the Cochrane risk of bias tool and Physiotherapy Evidence Database (PEDro) scale: A meta-epidemiological study of randomized controlled trials of physical therapy interventions. PLoS ONE, 14(9), 1-16. https://doi.org/10.1371/journal.pone.0222770
  • Neufer, P. D. (2018). The bioenergetics of exercise. Cold Spring Harbor Perspectives in Medicine, 8(5), 1-11. https://doi.org/10.1101/cshperspect.a029678
  • Opheim, M. N., & Rankin, J. W. (2012). Effect of capsaicin supplementation on repeated sprinting performance. Journal of Strength and Conditioning Research, 26(2), 319-326. https://doi.org/10.1519/JSC.0b013e3182429ae5
  • Ota, H., Katanosaka, K., Murase, S., Kashio, M., Tominaga, M., & Mizumura, K. (2013). TRPV1 and TRPV4 Play Pivotal Roles in Delayed Onset Muscle Soreness. PLoS ONE, 8(6). https://doi.org/10.1371/journal.pone.0065751
  • Piccolella, S., Crescente, G., Candela, L., & Pacifico, S. (2019). Nutraceutical polyphenols: New analytical challenges and opportunities. Journal of Pharmaceutical and Biomedical Analysis, 175, 112774. https://doi.org/10.1016/j.jpba.2019.07.022
  • Sanz-Salvador, L., Andrés-Borderia, A., Ferrer-Montiel, A., & Planells-Cases, R. (2012). Agonist- and Ca2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation. Journal of Biological Chemistry, 287(23), 19462-19471. https://doi.org/10.1074/jbc.M111.289751
  • Schmitt, J., & Ferro, A. (2013). Nutraceuticals: Is there good science behind the hype? British Journal of Clinical Pharmacology, 75(3), 585-587. https://doi.org/10.1111/bcp.12061
  • Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L. A., Altman, D. G., Booth, A., Chan, A. W., Chang, S., Clifford, T., Dickersin, K., Egger, M., Gøtzsche, P. C., Grimshaw, J. M., Groves, T., Helfand, M., … Whitlock, E. (2015). Preferred reporting items for systematic review and meta-analysis protocols (prisma-p) 2015: Elaboration and explanation. BMJ (Online), 349(January), 1-25. https://doi.org/10.1136/bmj.g7647
  • Sharma, S. K., Vij, A. S., & Sharma, M. (2013). Mechanisms and clinical uses of capsaicin. European Journal of Pharmacology, 720(1-3), 55-62. https://doi.org/10.1016/j.ejphar.2013.10.053
  • Taylor, J. L., Amann, M., Duchateau, J., Meeusen, R., & Rice, C. L. (2016). Neural Contributions to Muscle Fatigue. Medicine & Science in Sports & Exercise, 48(11), 2294-2306. https://doi.org/10.1249/mss.0000000000000923
  • Ulupınar, S., Özbay, S., Gençoğlu, C., Franchini, E., Kishalı, N. F., & İnce, İ. (2021). Effects of sprint distance and repetition number on energy system contributions in soccer players. Journal of Exercise Science and Fitness, 19(3), 182-188. https://doi.org/10.1016/j.jesf.2021.03.003
  • Urrutia, G., & Bonfill, X. (2010). PRISMA declaration: A proposal to improve the publication of systematic reviews and meta-analyses. Medicina Clínica, 135(11), 507-511. https://doi.org/10.1016/j.medcli.2010.01.015
  • Vianna, L. C., Fernandes, I. A., Barbosa, T. C., Teixeira, A. L., & Nóbrega, A. C. L. (2018). Capsaicin-based analgesic balm attenuates the skeletal muscle metaboreflex in healthy humans. Journal of Applied Physiology, 125(2), 362-368. https://doi.org/10.1152/japplphysiol.00038.2018
  • Vriens, J., Appendino, G., & Nilius, B. (2009). Pharmacology of vanilloid transient receptor potential cation channels. Molecular Pharmacology, 75(6), 1262-1279. https://doi.org/10.1124/mol.109.055624
  • Walter, A. A., Herda, T. J., Ryan, E. D., Costa, P. B., Hoge, K. M., Beck, T. W., Stout, J. R., & Cramer, J. T. (2009). Acute effects of a thermogenic nutritional supplement on cycling time to exhaustion and muscular strength in college-aged men. Journal of the International Society of Sports Nutrition, 6. https://doi.org/10.1186/1550-2783-6-15
  • Zając, A., Chalimoniuk, M., Gołas̈, A., Lngfort, J., & Maszczyk, A. (2015). Central and peripheral fatigue during resistance exercise - A critical review. Journal of Human Kinetics, 49(1), 159-169. https://doi.org/10.1515/hukin-2015-0118
  • Zhai, K., Liskova, A., Kubatka, P., & Büsselberg, D. (2020). Calcium entry through trpv1: A potential target for the regulation of proliferation and apoptosis in cancerous and healthy cells. International Journal of Molecular Sciences, 21(11), 1-25. https://doi.org/10.3390/ijms21114177
  • Zhang, S., Wang, D., Huang, J., Hu, Y., & Xu, Y. (2020). Application of capsaicin as a potential new therapeutic drug in human cancers. Journal of Clinical Pharmacy and Therapeutics, 45(1), 16-28. https://doi.org/10.1111/jcpt.13039
Fuente de los datos: Dialnet