Síntesis y evaluación de ligandos tau-selectivos basados en estructuras de oxindol como potenciales agentes de imagen PET para diagnóstico in vivo de la Enfermedad de Alzheimer y otras tauopatías

  1. GONZALEZ FUENTE, ANA MARIA
Dirigida por:
  1. Francisco Sánchez Sancho Director/a
  2. Aurelio García Csákÿ Director/a

Universidad de defensa: Universidad Complutense de Madrid

Fecha de defensa: 29 de marzo de 2022

Tribunal:
  1. Miguel Angel Pozo García Presidente/a
  2. María Angeles Canales Mayordomo Secretario/a
  3. Carlos del Pozo Losada Vocal
  4. Laura Lagartera Ortiz Vocal
  5. Antonio Marcilla Díaz Vocal

Tipo: Tesis

Resumen

Alzheimer ’s disease (AD) belongs to the pathology group named Taupathies. Currently, more than 24 million people suffer from Alzheimer disease and other dementias. This represents a serious health problem, especially if we take into account that the diagnosis of AD can only be confirmed by a postmortem histological analysis. So we need more effective and non-invasive techniques for early diagnosis.AD presents two biomarkers: tau protein and amyloid β peptide. Tau protein is the main microtubule-associated protein, responsible for axonal stabilization, which allows the proper neuronal transport. In its aberrant form, tau undergo a process of hyperphosphorilation that leads to an abnormal aggregation, forming Paired Helicoidal Filaments (PHFs) and Neurofibrillary Tangles (NFTs) in the intraneuronal medium. This process drives to the loss of the biological activity of tau and as a consequence, the cognitive decline. In addition, the other biomarker in Alzheimer's disease, the β-amyloid peptide aggregates as an extracellular deposit, forming senile plaques (SPs), which can trigger a local inflammatory response...