Antioxidant capacity of 5-Fluorouracile and new fluorinated uracil derivates

  1. Carlos Casanova Sorní 1
  2. María Luz Moreno Sancho 2
  3. María Miranda Sanz 1
  4. Inmaculada Almansa Frías 1
  5. Antonio Falcó Montesinos 1
  6. María Ángeles Navarro Moreno 2
  7. Santos Fustero Lardíes 3
  8. Salvador Mérida Donoso 1
  9. Vicente M. Villar Amigó 1
  1. 1 Department of Biomedical Sciences. School of Health Sciences. Universidad Cardenal Herrera-CEU
  2. 2 Department of Basic Sciences. School of Physical Activity and Sport Sciences. Universidad Católica de Valencia San Vicente Mártir.
  3. 3 Department of Organic Chemistry. School of Pharmacy. Universitat de València.
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Journal:
Nereis: revista iberoamericana interdisciplinar de métodos, modelización y simulación

ISSN: 1888-8550

Year of publication: 2018

Issue: 10

Pages: 99-105

Type: Article

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More publications in: Nereis: revista iberoamericana interdisciplinar de métodos, modelización y simulación

Abstract

Oxidative stress is associated with multiple pathologies such as cancer and can exacerbate the development of them. In this work, we have studied the antioxidant capacity of 5-Fluorouracile (5-FU) which is an antineoplastic drug that is used in the treatment of colorectal cancer. 5-FU is a compound that has a chemical structure similar to uracil and is also fluorinated. New fluorinated derivates previously obtained in our laboratory were tested to study its antioxidant activity. All the compounds analyzed were able to inhibit lipid peroxidation when used in concentrations of 10 µM.

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