Més enllà de la doble hèlix

  1. Pont Niclós, Isabel 1
  2. González García, Jorge 1
  1. 1 Universitat de València
    info

    Universitat de València

    Valencia, España

    ROR https://ror.org/043nxc105

Revista:
Mètode: Revista de difusió de la investigació

ISSN: 1133-3987

Año de publicación: 2021

Volumen: 2

Número: 109

Páginas: 32-39

Tipo: Artículo

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Otras publicaciones en: Mètode: Revista de difusió de la investigació

Resumen

DNA is the fundamental biomolecule needed for correct cell functioning and, until very recently, it was associated to the double helix structure discovered over 70 years ago by Crick, Watson, and Franklin. However, other DNA structures and conformations have been described, like G-quadruplexes. These G-quadruplexes are formed in regions of the genome that are rich in guanine. They have tetramer structure and control biological processes such as genetic expression, protection against ageing, or the transmission of neural information. In this document, we describe their chemical and structural characteristics, besides presenting their main cellular functions. Lastly, we present G-quadruplexes as molecular targets for future cancer therapies.

Referencias bibliográficas

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Fuente de los datos: Dialnet