Depression and Suicide Risk in Mild Cognitive Impairmentthe Role of Alzheimer’s Disease Biomarkers

  1. Inés Ferrer-Cairols 1
  2. Teresa Montoliu 1
  3. Isabel Crespo-Sanmiguel 1
  4. MatiasM. Pulopulos 1
  5. Vanesa Hidalgo 2
  6. Enriqueta Gómez
  7. Rogelio López-Cuevas
  8. Ana Cuevas
  9. Núria Martín
  10. Miguel Baquero
  11. Alicia Salvador 1
  1. 1 Universitat de València
    info

    Universitat de València

    Valencia, España

    ROR https://ror.org/043nxc105

  2. 2 Universidad de Zaragoza
    info

    Universidad de Zaragoza

    Zaragoza, España

    ROR https://ror.org/012a91z28

Revista:
Psicothema

ISSN: 0214-9915 1886-144X

Año de publicación: 2022

Volumen: 34

Número: 4

Páginas: 553-561

Tipo: Artículo

DOI: 10.7334/PSICOTHEMA2022.103 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Psicothema

Resumen

Los pacientes con depresión y deterioro cognitivo leve (DCL) tienen un alto riesgo de desarrollar demencia. La depresión implica un alto riesgo de ideación suicida (IS) e intentos de suicidio (AS). Los biomarcadores de la enfermedad de Alzheimer (EA) pueden clarificar el papel de la depresión e IS en la EA. Método: Cincuenta y nueve participantes >50 años con criterios de DCL-EA positivo (DCL-EA; 22) y negativo (DCL-NoEA; 24) y 13 controles sanos. La depresión fue evaluada con la Escala Geriátrica de Depresión (GDS-30) y la IS con el factor GDS-IS. Además, se midieron los siguientes biomarcadores en el líquido cefalorraquídeo: ß-amiloide (ß-A), tau hiperfosforilada (H-tau) y total (T-tau). Resultados: No se encontraron diferencias significativas entre los tres grupos de participantes en depresión o en IS. Sin embargo, en el grupo DCL-EA, niveles más bajos de H-tau y T-tau, indicadores de menor patología EA, se relacionaron significativamente con mayor riesgo de suicidio indirecto. Conclusiones: Este resultado subraya la importancia de considerar la IS en fases iniciales de EA, y el potencial papel de los biomarcadores de EA para detectar sus síntomas.

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