Effect of physical activity on COVID-19 symptomsA narrative review
- NICOLE B. FRITZ
- JAVIER GENE-MORALES
- ANGEL SAEZ-BERLANGA
- CARLOS BABILON-ILÓPEZ
- ÁLVARO JUESAS
- JUAN CARLOS COLADO
ISSN: 1988-5202
Año de publicación: 2021
Título del ejemplar: Spring Conferences of Sports Science
Volumen: 16
Número: 4
Páginas: 2042-2056
Tipo: Artículo
Otras publicaciones en: Journal of Human Sport and Exercise: JHSE
Resumen
In 2019, a new condition caused by the COVID-19, became a global pandemic, presenting a disparate symptomatological picture. The immune response to the virus depends on multiple factors, making the practice of physical exercise an important enhancer of the immune system, but it is unknown what effects it could have on the very different symptoms. In order to achieve and summarize the most outstanding information on the influence of the different types and parameters of physical exercise on the immune system and symptoms presented by COVID-19, it was decided to carry out a review of the literature in the databases PubMed and Medline until August 2020. The results showed that while high intensity and prolonged volume exercise produces counterproductive alterations in the immune system, increasing the possibility of contracting infections; low and moderate intensity exercise reverses these effects, increasing the benefits, providing the body with better protection against viruses. For the symptoms of COVID-19 related to cough, dyspnea, pulmonary obstruction, hypoxia, muscle pain and neuromuscular conditions, exercise at low and moderate intensity is recommended, while those people who present gastrointestinal symptoms and fatigue are recommended to exercise at low intensity. Exercise is completely contraindicated in case of fever and myocarditis.
Referencias bibliográficas
- Ament, W., & Verkerke, G. J. (2009). Exercise and Fatigue. Sports Medicine, 39(5), 389-422. https://doi.org/10.2165/00007256-200939050-00005
- Andersen, C. J., Murphy, K. E., & Fernandez, M. L. (2016). Impact of Obesity and Metabolic Syndrome on Immunity. Advances in Nutrition, 7(1), 66-75. https://doi.org/10.3945/an.115.010207
- Aranda, F. (2006). Presentación por escrito de la revisión bibliográfica. Buenos Aires. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Available at: http://paveca3.blogspot.com/2010/11/presentacion-por-escrito-dela-revision.html
- Ayres, J. S. (2020). A metabolic handbook for the COVID-19 pandemic. Nature Metabolism, 2(7), 572-585. https://doi.org/10.1038/s42255-020-0237-2
- Bellar, D. M., Muller, M. D., Barkley, J. E., Kim, C. H., Ida, K., Ryan, E. J., Bliss, M. V., & Glickman, E. L. (2011). The Effects of Combined Elastic- and Free-Weight Tension vs. Free-Weight Tension on One-Repetition Maximum Strength in the Bench Press. Journal of Strength and Conditioning Research, 25(2), 459-463. https://doi.org/10.1519/jsc.0b013e3181c1f8b6
- Bossenbroek, L., de Greef, M. H., Wempe, J. B., Krijnen, W. P., & ten Hacken, N. H. (2011). Daily Physical Activity in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review. COPD: Journal of Chronic Obstructive Pulmonary Disease, 8(4), 306-319. https://doi.org/10.3109/15412555.2011.578601
- Broom, M. (2007). Physiology of fever. Paediatric Nursing, 19(6), 40-44. https://doi.org/10.7748/paed.19.6.40.s32
- Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J., Yu, T., Zhang, X., & Zhang, L. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet, 395(10223), 507-513. https://doi.org/10.1016/s0140-6736(20)30211-7
- Chowdhury, M. A., Hossain, N., Kashem, M. A., Shahid, M. A., & Alam, A. (2020). Immune response in COVID-19: A review. Journal of Infection and Public Health, 13(11), 1619-1629. https://doi.org/10.1016/j.jiph.2020.07.001
- da Silveira, M. P., da Silva Fagundes, K. K., Bizuti, M. R., Starck, D., Rossi, R. C., & de Resende e Silva, D. T. (2020). Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature. Clinical and Experimental Medicine, 21(1), 15-28. https://doi.org/10.1007/s10238-020-00650-3
- Damiot, A., Pinto, A., Turner, J., & Gualano, B. (2020). Immunological Implications of Physical Inactivity among Older Adults during the COVID-19 Pandemic. Gerontology, 66(5), 431-438. https://doi.org/10.1159/000509216
- Demoulin-Alexikova, S., Marchal, F., Bonabel, C., Demoulin, B., Foucaud, L., Coutier-Marie, L., Schweitzer, C. E., & Ioan, I. (2017). Down-Regulation of Cough during Exercise Is Less Frequent in Healthy Children than Adults. Role of the Development and/or Atopy? Frontiers in Physiology, 8. https://doi.org/10.3389/fphys.2017.00304
- Denay, K. L., Breslow, R. G., Turner, M. N., Nieman, D. C., Roberts, W. O., & Best, T. M. (2020). ACSM Call to Action Statement: COVID-19 Considerations for Sports and Physical Activity. Current Sports Medicine Reports, 19(8), 326-328. https://doi.org/10.1249/jsr.0000000000000739
- Dick, N. A., & Diehl, J. J. (2013). Febrile Illness in the Athlete. Sports Health: A Multidisciplinary Approach, 6(3), 225-231. https://doi.org/10.1177/1941738113508373
- Egerton, T., Chastin, S. F. M., Stensvold, D., & Helbostad, J. L. (2015). Fatigue May Contribute to Reduced Physical Activity Among Older People: An Observational Study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(5), 670-676. https://doi.org/10.1093/gerona/glv150
- Elgert, K. D. (2009). Immunology: understanding the immune system. John Wiley & Sons.
- Eichhorn, C., Bière, L., Schnell, F., Schmied, C., Wilhelm, M., Kwong, R. Y., & Gräni, C. (2020). Myocarditis in Athletes Is a Challenge. JACC: Cardiovascular Imaging, 13(2), 494-507. https://doi.org/10.1016/j.jcmg.2019.01.039
- Eckert, D. J., Catcheside, P. G., Stadler, D. L., McDonald, R., Hlavac, M. C., & McEvoy, R. D. (2006). Acute sustained hypoxia suppresses the cough reflex in healthy subjects. American journal of respiratory and critical care medicine, 173(5), 506-511. https://doi.org/10.1164/rccm.200509-1455OC
- Ferreira, M. J., Irigoyen, M. C., Consolim-Colombo, F., Saraiva, J. F. K., & De Angelis, K. (2020). Vida Fisicamente Ativa como Medida de Enfrentamento ao COVID-19. Arquivos Brasileiros de Cardiologia. Published. https://doi.org/10.36660/abc.20200235
- Gleeson, M., Bishop, N., Oliveira, M., McCauley, T., Tauler, P., & Muhamad, A. S. (2011). Respiratory infection risk in athletes: association with antigen-stimulated IL-10 production and salivary IgA secretion. Scandinavian Journal of Medicine & Science in Sports, 22(3), 410-417. https://doi.org/10.1111/j.1600-0838.2010.01272.x
- Guan, W. J., Ni, Z. Y., Hu, Y., Liang, W. H., Ou, C. Q., He, J. X., Liu, L., Shan, H., Lei, C. L., Hui, D. S., Du, B., Li, L. J., Zeng, G., Yuen, K. Y., Chen, R. C., Tang, C. L., Wang, T., Chen, P. Y., Xiang, J., . . . Zhong, N. S. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine, 382(18), 1708-1720. https://doi.org/10.1056/nejmoa2002032
- Guo, Y. R., Cao, Q. D., Hong, Z. S., Tan, Y. Y., Chen, S. D., Jin, H. J., Tan, K. S., Wang, D. Y., & Yan, Y. (2020). The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Military Medical Research, 7(1). https://doi.org/10.1186/s40779-020-00240-0
- Guyton, A. C., & Hall, J. E. (2011). Fisiologia Medica (11.a ed.). Elsevier Science Health Science Div.
- Halle, M., Binzenhöfer, L., Mahrholdt, H., Johannes Schindler, M., Esefeld, K., & Tschöpe, C. (2020). Myocarditis in athletes: A clinical perspective. European Journal of Preventive Cardiology. Published. https://doi.org/10.1177/2047487320909670
- Hammami, A., Harrabi, B., Mohr, M., & Krustrup, P. (2020). Physical activity and coronavirus disease 2019 (COVID-19): specific recommendations for home-based physical training. Managing Sport and Leisure, 1-6. https://doi.org/10.1080/23750472.2020.1757494
- Harris, M. D. (2011). Infectious Disease in Athletes. Current Sports Medicine Reports, 10(2), 84-89. https://doi.org/10.1249/jsr.0b013e3182142381
- Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., . . . Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395(10223), 497-506. https://doi.org/10.1016/s0140-6736(20)30183-5
- Kantorowski, A., Wan, E. S., Homsy, D., Kadri, R., Richardson, C. R., & Moy, M. L. (2018). Determinants and outcomes of change in physical activity in COPD. ERJ Open Research, 4(3), 00054-02018. https://doi.org/10.1183/23120541.00054-2018
- Katajisto, M., Kupiainen, H., Rantanen, Kilpeläinen, Lindqvist, A., Tikkanen, & Laitinen, T. (2012). Physical inactivity in COPD and increased patient perception of dyspnea. International Journal of Chronic Obstructive Pulmonary Disease, 743. https://doi.org/10.2147/copd.s35497
- Lancaster, G. I., Halson, S. L., Khan, Q., Drysdale, P., Wallace, F., Jeukendrup, A. E., Drayson, M. T., & Gleeson, M. (2004). Effects of acute exhaustive exercise and chronic exercise training on type 1 and type 2 T lymphocytes. Exercise immunology review, 10, 91-106.
- Lancaster, G. I., Khan, Q., Drysdale, P. T., Wallace, F., Jeukendrup, A. E., Drayson, M. T., & Gleeson, M. (2005). Effect of prolonged exercise and carbohydrate ingestion on type 1 and type 2 T lymphocyte distribution and intracellular cytokine production in humans. Journal of Applied Physiology, 98(2), 565-571. https://doi.org/10.1152/japplphysiol.00754.2004
- Liu, J., Li, S., Liu, J., Liang, B., Wang, X., Wang, H., Li, W., Tong, Q., Yi, J., Zhao, L., Xiong, L., Guo, C., Tian, J., Luo, J., Yao, J., Pang, R., Shen, H., Peng, C., Liu, T., . . . Zheng, X. (2020). Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. EBioMedicine, 55, 102763. https://doi.org/10.1016/j.ebiom.2020.102763
- Maron, B. J., Levine, B. D., Washington, R. L., Baggish, A. L., Kovacs, R. J., & Maron, M. S. (2015). Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 2: Preparticipation Screening for Cardiovascular Disease in Competitive Athletes. Circulation, 132(22). https://doi.org/10.1161/cir.0000000000000238
- Martins, W. R., de Oliveira, R. J., Carvalho, R. S., de Oliveira Damasceno, V., da Silva, V. Z. M., & Silva, M. S. (2013). Elastic resistance training to increase muscle strength in elderly: A systematic review with meta-analysis. Archives of Gerontology and Geriatrics, 57(1), 8-15. https://doi.org/10.1016/j.archger.2013.03.002
- Mitchell, R. N., Kumar, V., Abbas, A. K., & Aster, J. C. (Eds.). (2017). Compendio de Robbins y Cotran. Patología estructural y funcional. Elsevier Health Sciences.
- Mohammadi, S., Moosaie, F., & Aarabi, M. H. (2020). Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms. Molecular Neurobiology, 57(12), 5263-5275. https://doi.org/10.1007/s12035-020-02094-y
- Narici, M., Vito, G. D., Franchi, M., Paoli, A., Moro, T., Marcolin, G., Grassi, B., Baldassarre, G., Zuccarelli, L., Biolo, G., di Girolamo, F. G., Fiotti, N., Dela, F., Greenhaff, P., & Maganaris, C. (2020). Impact of sedentarism due to the COVID-19 home confinement on neuromuscular, cardiovascular and metabolic health: Physiological and pathophysiological implications and recommendations for physical and nutritional countermeasures. European Journal of Sport Science, 21(4), 614-635. https://doi.org/10.1080/17461391.2020.1761076
- Nieman, D. C., & Wentz, L. M. (2019). The compelling link between physical activity and the body's defense system. Journal of sport and health science, 8(3), 201-217. https://doi.org/10.1016/j.jshs.2018.09.009
- Nyenhuis, S. M., Greiwe, J., Zeiger, J. S., Nanda, A., & Cooke, A. (2020). Exercise and Fitness in the Age of Social Distancing During the COVID-19 Pandemic. The Journal of Allergy and Clinical Immunology: In Practice, 8(7), 2152-2155. https://doi.org/10.1016/j.jaip.2020.04.039
- Peake, J. M., Della Gatta, P., Suzuki, K., & Nieman, D. C. (2015). Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects. Exercise immunology review, 21, 8-25.
- Peake, J. M., Neubauer, O., Walsh, N. P., & Simpson, R. J. (2017). Recovery of the immune system after exercise. Journal of Applied Physiology, 122(5), 1077-1087. https://doi.org/10.1152/japplphysiol.00622.2016
- Pelliccia, A., Solberg, E. E., Papadakis, M., Adami, P. E., Biffi, A., Caselli, S., La Gerche, A., Niebauer, J., Pressler, A., Schmied, C. M., Serratosa, L., Halle, M., Van Buuren, F., Borjesson, M., Carrè, F., Panhuyzen-Goedkoop, N. M., Heidbuchel, H., Olivotto, I., Corrado, D., . . . Sharma, S. (2018). Recommendations for participation in competitive and leisure time sport in athletes with cardiomyopathies, myocarditis, and pericarditis: position statement of the Sport Cardiology Section of the European Association of Preventive Cardiology (EAPC). European Heart Journal, 40(1), 19-33. https://doi.org/10.1093/eurheartj/ehy730
- Peters, H. P., De Vries, W. R., Vanberge-Henegouwen, G. P., & Akkermans, L. M. (2001). Potential benefits and hazards of physical activity and exercise on the gastrointestinal tract. Gut, 48(3), 435-439. https://doi.org/10.1136/gut.48.3.435
- Peters, H. P. F. (2001). Potential benefits and hazards of physical activity and exercise on the gastrointestinal tract. Gut, 48(3), 435-439. https://doi.org/10.1136/gut.48.3.435
- Prompetchara, E., Ketloy, C., & Palaga, T. (2020). Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pacific journal of allergy and immunology, 38(1), 1-9. https://doi.org/10.12932/AP-200220-0772
- Puetz, T. W. (2006). Physical Activity and Feelings of Energy and Fatigue. Sports Medicine, 36(9), 767-780. https://doi.org/10.2165/00007256-200636090-00004
- Raiol, R. A. (2020). Praticar exercícios físicos é fundamental para a saúde física e mental durante a Pandemia da COVID-19. Brazilian Journal of Health Review, 3(2), 2804-2813. https://doi.org/10.34119/bjhrv3n2-124
- Sanchis-Gomar, F., Lavie, C. J., Mehra, M. R., Henry, B. M., & Lippi, G. (2020). Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide. Mayo Clinic Proceedings, 95(7), 1445-1453. https://doi.org/10.1016/j.mayocp.2020.05.006
- Shin, K. C. (2018). Physical activity in chronic obstructive pulmonary disease: clinical impact and risk factors. The Korean Journal of Internal Medicine, 33(1), 75-77. https://doi.org/10.3904/kjim.2017.387
- Simpson, R. J., Campbell, J. P., Gleeson, M., Krüger, K., Nieman, D. C., Pyne, D. B., Turner, J. E., & Walsh, N. P. (2020). Can exercise affect immune function to increase susceptibility to infection?. Exercise immunology review, 26, 8-22.
- Søgaard, K., & Sjøgaard, G. (2017). Physical Activity as Cause and Cure of Muscular Pain: Evidence of Underlying Mechanisms. Exercise and Sport Sciences Reviews, 45(3), 136-145. https://doi.org/10.1249/jes.0000000000000112
- Steinacker, J., Bloch, W., Halle, H., Mayer, F., Meyer, T., Hirschmüller, A., Röcker, K., Nieß, A., Scharhag, J., Reinsberger, C., Scherr, J., Niebauer, J., Wolfarth, B., Hannafin, J., Hiura, M., Wilkinson, M., Koubaa, D., Poli, P., Smoljanovic, T., . . . Wilson, F. (2020). Fact Sheet: Health Situation for Athletes in the Current Coronavirus Pandemic (SARS-CoV-2 / COVID-19). Deutsche Zeitschrift für Sportmedizin, 71(4), 85-86. https://doi.org/10.5960/dzsm.2020.431
- Svendsen, I. S., Hem, E., & Gleeson, M. (2016). Effect of acute exercise and hypoxia on markers of systemic and mucosal immunity. European Journal of Applied Physiology, 116(6), 1219-1229. https://doi.org/10.1007/s00421-016-3380-4
- Ter Steege, R. W. F., Van Der Palen, J., & Kolkman, J. J. (2008). Prevalence of gastrointestinal complaints in runners competing in a long-distance run: An internet-based observational study in 1281 subjects. Scandinavian Journal of Gastroenterology, 43(12), 1477-1482. https://doi.org/10.1080/00365520802321170
- Timpka, T. (2020). Sports Health During the SARS-Cov-2 Pandemic. Sports Medicine, 50(8), 1413-1416. https://doi.org/10.1007/s40279-020-01288-7
- Troosters, T., Sciurba, F., Battaglia, S., Langer, D., Valluri, S. R., Martino, L., Benzo, R., Andre, D., Weisman, I., & Decramer, M. (2010). Physical inactivity in patients with COPD, a controlled multi-center pilot-study. Respiratory Medicine, 104(7), 1005-1011. https://doi.org/10.1016/j.rmed.2010.01.012
- Wang, X., Liu, W., Zhao, J., Lu, Y., Wang, X., Yu, C., Hu, S., Shen, N., Liu, W., Sun, Z., & Li, W. (2020). Clinical characteristics of 80 hospitalized frontline medical workers infected with COVID-19 in Wuhan, China. Journal of Hospital Infection, 105(3), 399-403. https://doi.org/10.1016/j.jhin.2020.04.019
- Wu, F., Zhao, S., Yu, B., Chen, Y. M., Wang, W., Song, Z. G., Hu, Y., Tao, Z. W., Tian, J. H., Pei, Y. Y., Yuan, M. L., Zhang, Y. L., Dai, F. H., Liu, Y., Wang, Q. M., Zheng, J. J., Xu, L., Holmes, E. C., & Zhang, Y. Z. (2020). A new coronavirus associated with human respiratory disease in China. Nature, 579(7798), 265-269. https://doi.org/10.1038/s41586-020-2008-3
- WHO. World Health Organization. Coronavirus disease (COVID- 19) Pandemic [Internet]. 2020. Retrieved from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019 Access 1 august 2020.