Enzimas de la biosíntesis del virus SARS-CoV-2 como dianas potenciales para el descubrimiento de nuevos antivirales

  1. Castillo-Garit, Juan Alberto 1
  2. Cañizares-Carmenate, Yudith 2
  3. Pérez-Giménez, Facundo 3
  1. 1 Unidad de Toxicología Experimental. Universidad de Ciencias Médicas de Villa Clara.(Cuba)
  2. 2 Unit of Computer-Aided Molecular “Biosilico” Discovery and Bioinformatic Research (CAMD-BIR Unit), Facultad de Química-Farmacia. Universidad Central “Marta Abreu” de Las Villas. Santa Clara 54830. Villa Clara. Cuba.
  3. 3 Unidad de Investigación de Diseño de Fármacos y Conectividad Molecular. Departamento de Química Física. Facultad de Farmacia. Universitat de València. España.
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Zeitschrift:
Nereis: revista iberoamericana interdisciplinar de métodos, modelización y simulación

ISSN: 1888-8550

Datum der Publikation: 2021

Nummer: 13

Seiten: 17-23

Art: Artikel

DOI: 10.46583/NEREIS_2021.13.844 DIALNET GOOGLE SCHOLAR lock_openDialnet editor

Andere Publikationen in: Nereis: revista iberoamericana interdisciplinar de métodos, modelización y simulación

Zusammenfassung

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised a major global health concern. This urgent situation is pressing the world to respond with the development of novel vaccine or small molecule therapeutics for SARS-CoV-2. Drug repurposing screening is regarded as one of the most practical and rapid approaches for the discovery of such therapeutics. Direct-acting agents, targeting specific viral enzymes that play an essential role in viral replication, represent a milestone in antiviral therapy. Several biosynthetic enzymes of the SARS-CoV-2 were analyzed as potential targets to develop new therapeutic drugs. This work provides a basis and directions for future drug development and reuse on the protein level of COVID-19.

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Fuente de los datos: Dialnet