Cardiovascular response to stress in patients with drug-resistant epilepsypreliminary data

  1. Alejandro Lozano García 1
  2. Judit Catalán 12
  3. Kevin Hampel 3
  4. Vicente Villanueva 3
  5. Esperanza González-Bono 1
  6. Irene Cano-López 1
  1. 1 Universitat de València
    info

    Universitat de València

    Valencia, España

    ROR https://ror.org/043nxc105

  2. 2 Universidad Internacional de Valencia
    info

    Universidad Internacional de Valencia

    Valencia, España

    ROR https://ror.org/00gjj5n39

  3. 3 Hospital Universitario La Fe
    info

    Hospital Universitario La Fe

    Valencia, España

    ROR https://ror.org/01ar2v535

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Revista:
Anales de psicología

ISSN: 0212-9728,  1695-2294

Año de publicación: 2021

Título del ejemplar: Cerebro y conducta: un enfoque neurocientífico/psicofisiológico

Volumen: 37

Número: 3

Páginas: 440-448

Tipo: Artículo

DOI: 10.6018/ANALESPS.483021 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Anales de psicología

Resumen

El estrés es un factor de riesgo para las enfermedades cardiovasculares en la población general. La epilepsia se ha considerado un modelo adecuado de estrés crónico, con mayor incidencia de mortalidad cardiovascular que la población general. Este estudio proporciona datos preliminares sobre la respuesta cardiovascular ante un estresor cognitivo y una evaluación neuropsicológica en pacientes con epilepsia, explorando las relaciones entre la respuesta cardiovascular y el rendimiento cognitivo dependiendo del hemisferio responsable de la epilepsia. Treinta y cinco pacientes con epilepsia farmacorresistente, 17 con el área epileptógena(AE) en el hemisferio izquierdo (LH) y 18 con AE en el hemisferio derecho (RH), se sometieron a un estres cognitivo y una evaluación neuropsicológica. La respuesta cardiovascular se registró durante toda la sesión en ambas condiciones. Los resultados mostraron que una evaluación neuropsicológica de larga duración fue capaz de producir una respuesta cardiovascular modulada por el hemisferio, con disminuciones de la frecuencia cardíaca (y aumentos del intervalo RR) más pronunciadas en el período post-evaluación en pacientes con epilepsia del HI que en pacientes con epilepsia del HD (p = .05, p = .01, respectivamente). El hemisferio del AE moderó la relación entre la respuesta cardiovascular y el rendimiento cognitivo (para todos, p < .03). Nuestros hallazgos podrían tener implicaciones clínicas desde una perspectiva preventiva, ya que sugieren que el hemisferio del AE podría ser un factor relevante en el afrontamiento del estrés en personas con epilepsia farmacorresistente.

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Información de financiación

Acknowledgments.- This work was supported by the Spanish Ministry of Economy and Competitiveness and the European Regional Development Fund (MINECO/FEDER) [grant number PSI2015-66600-P, 2015]. The authors are grateful to John Rawlins for the revision of English style and grammar.

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Fuente de los datos: Dialnet