Perfil clínico de los pacientes con hipertrigliceridemia muy severa del Registro de Hipertrigliceridemias de la Sociedad Española de Arteriosclerosis
- Pedragosa, Àngels
- Merino Ribas, Jordi
- Aranda Arcas, José Luis
- Galiana, Jesús
- Godoy, Diego
- Panisello Royo, Josefa María
- Ascaso Gimilio, Juan Francisco
- Civeira Murillo, Fernando
- Masana Marín, Lluís
- Pedro-Botet Montoya, Juan
ISSN: 0214-9168, 1578-1879
Año de publicación: 2013
Volumen: 25
Número: 1
Páginas: 8-15
Tipo: Artículo
Otras publicaciones en: Clínica e investigación en arteriosclerosis
Resumen
Background and objective: To describe clinical and epidemiological characteristics of patients with very high hypertriglyceridemia (HTG) who were attended in lipid units of the Spanish Society of Atherosclerosis (SEA). Patients and method: Patients of the HTG Registry of SEA with at least one triglyceride concentration greater than 1,000 mg/dL (n = 298, HTG severe group) and those whose baseline triglycerides were between 200 and 246 mg/dL (HTG control group, n = 272) were included. Results: Patients with very high triglyceride levels were younger (46.9 ± 11.5 years vs 52.7 ± 13 years; p < 0.0001), with a larger waist circumference (100.5 ± 10.6 cm vs 98.5 ± 11.1 cm; p = 0.0426), higher alcohol intake (170.7 ± 179.1 g/wk vs 118.8 ± 106.4 g/wk; p = 0,0473), active smoking status (45.6% vs 26.8%; p < 0.0001) and a higher frequency of pancreatitis (10.2% vs 3%; p = 0.0006) than HTG control group. There was a higher percentage of patients with atherogenic dietary pattern in severe HTG group compared with the control group (138 [46.3%] vs. 94 [34.5%]; p = 0,001). The multivariate analysis showed that factors associated with a triglyceride concentration greater than 1,000 mg/dl were age, male sex, weight, waist circumference, alcohol, physical inactivity in non-business hours and the presence of diabetes mellitus. Conclusions: Patients with very high HTG were usually men in the fourth decade of life, with abdominal obesity, smoking and alcohol consumption. In 60% of cases the HTG was primary, and pancreatitis the most frequently complication.