Características clínicas y epidemiológicas de la población pediátrica diagnosticada de Diabetes Mellitus Tipo 120 años de evolución en Cantabria

  1. Bertholt Zuber, María Laura
Supervised by:
  1. Domingo González-Lamuño Leguina Director
  2. Cristina Luzuriaga Tomás Director

Defence university: Universidad de Cantabria

Fecha de defensa: 10 February 2016

Committee:
  1. Luis Castaño González Chair
  2. Jesús Lino Álvarez Granda Secretary
  3. María José López García Committee member

Type: Thesis

Teseo: 406108 DIALNET lock_openUCrea editor

Abstract

Objectives: to characterize the pediatric population of Cantabria diagnosed of DM1. Population and methods: retrospective study of patients <15 years, diagnosed between 01/01/1995 and 31/12/2014. Variables: sex, origin, seasonality, background. At debut: age, clinical presentation, evolution, analytical, pancreatic reserve, HLA II, HbA1c, pancreatic ß cell antibodies, autoimmune disease. Calculation of incidences and trends in the period. Comparison between groups. Results: 207 patients: 51% female. Average age at debut 8.8±3.7 years: 0-4 years 16%, 5-9 years 38%, 10-14 years 4%. Slight predominance in winter 31.9% (p=0.04). Family history: DM1 15.5%, 10.6% other autoimmune diseases. Average hospital stay 8.5±2.9 days. Results debut: glucose 446.2±161.7mg/dl; pH 7.3±0.1; bicarbonate 17.4±5.8mEq/l; cetonemia4,1 ± 2,4mmol/l; HbA1c 11.4 ± 2.3%. Debut�s ketoacidosis percentage 42%, increase of 0.5% per year (p> 0.05). Variable annual incidence average 14.1 cases/100,000 (6 to 25.8); annual rise of 2.08% (p> 0.05). Incidence by health zones with marked variability; regions above 30/100,000; 4 rural low incidence (<5/100,000).