Effect on osseointegration of two implant macro-designsa histomorphometric analysis of bicortically installed implants in different topographic sites of rabbit’s tibiae

  1. David Soto Penaloza 1
  2. Marco Caneva 2
  3. José Viña Almunia 1
  4. José Javier Martín de Llano 3
  5. Berta García Mira 1
  6. David Peñarrocha Oltra 1
  7. Daniele Botticelli 2
  8. Miguel Peñarrocha Diago 1
  1. 1 Oral Surgery and Implantology Division, Stomatology Department, University of Valencia, Valencia, Spain
  2. 2 ARDEC Academy, Ariminum Odontologica, Rimini, Italy
  3. 3 Department of Pathology and Health Research Institute of the Hospital Clínico (INCLIVA), Faculty of Medicine and Dentistry, University of Valencia, Valencia, Spain
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Revista:
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Año de publicación: 2019

Volumen: 24

Número: 4

Páginas: 4

Tipo: Artículo

DOI: 10.4317/MEDORAL.22825 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Resumen

To evaluate the effect of two different implant macro-designs on the sequential osseointegration at bicortically installed implants in the rabbit tibia. A further aim is to compare the osseointegration at different topographic zones. 27 New Zealand rabbits were implemented. Two implants, one for each macro-design (Ticare Inhex® or Ticare Quattro®, Mozo-Grau, Valladolid, Spain), were randomly implanted in the diaphysis or metaphysis of each tibia. The flaps were sutured to allow a submerged healing. The animals were sacrificed after 2, 4 or 8 weeks. Ground sections were prepared and analyzed. No statistically significant differences were found between the two groups for newly formed bone in contact with the implant surface, being about 16%, 19% and 33% in both groups, after 2, 4, and 8 weeks of healing. Bone apposition was slightly higher in the diaphysis, reaching values of 36.4% in the diaphysis, and 29.3% in the metaphysis at 8 weeks of healing. It was observed that the implant position showed a statistical significance regarding BIC values at 4 and 8 weeks (p<0.05). Multivariate analysis fails to detect statistical significant differences for the interaction between implant designs and topographic site. Ticare Quattro® design had a slight better BIC values at diaphysis sites across healing stages, but without reaching a statistical significance. The both implant macro-designs provided similar degrees of osseointegration. Bone morphometry and density may affect bone apposition onto the implant surface. The apposition rates were slightly better in diaphysis compared to metaphysis.

Referencias bibliográficas

  • Schroeder, A,Pohler, O,Sutter, F. (1976). [Tissue reaction to an implant of a titanium hollow cylinder with a titanium surface spray layer]. Schweizerische Monatsschrift fur Zahnheilkd. 86. 713
  • Albrektsson, T,Eriksson, AR,Friberg, B,Lekholm, U,Lindahl, L,Nevins, M. (1993). Histologic investigations on 33 retrieved Nobelpharma implants. Clin Mater. 12. 1-9
  • Botticelli, D,Lang, NP. (2017). Dynamics of osseointegration in various human and animal models - a comparative analysis. Clin Oral Implants Res. 28. 742
  • Lioubavina-Hack, N,Lang, NP,Karring, T. (2006). Significance of primary stability for osseointegration of dental implants. Clin Oral Implants Res. 17. 244
  • Marco, F,Milena, F,Gianluca, G,Vittoria, O. (2005). Peri-implant osteogenesis in health and osteoporosis. Micron. 36. 630
  • Raghavendra, S,Wood, MC,Taylor, TD. (2005). Early wound healing around endosseous implants: a review of the literature. Int J Oral Maxillofac Implants. 20. 425
  • Davies, J. (2003). Understanding peri-implant endosseous healing. J Dent Educ. 67. 932
  • Abrahamsson, I,Berglundh, T,Linder, E,Lang, NP,Lindhe, J. (2003). Early bone formation adjacent to rough and turned endosseous implant surfaces. An experimental study in the dog. Clin Oral Implants Res. 15. 381
  • Halldin, A,Jimbo, R,Johansson, CB,Wennerberg, A,Jacobsson, M,Albrektsson, T. (2011). The effect of static bone strain on implant stability and bone remodeling. Bone. 49. 783
  • Chowdhary, R,Jimbo, R,Thomsen, CS,Carlsson, L,Wennerberg, A. (2014). The osseointegration stimulatory effect of macrogeometry-modified implants: A study in the rabbit. Clin Oral Implants Res. 25. 1051
  • Ivanoff, CJ,Gröndahl, K,Sennerby, L,Bergström, C,Lekholm, U. (1999). Influence of variations in implant diameters: a 3- to 5-year retrospective clinical report. Int J Oral Maxillofac Implants. 14. 173
  • Brunski, JB. (1988). Biomaterials and biomechanics in dental implant design. Int J Oral Maxillofac Implants. 3. 85-97
  • Abuhussein, H,Pagni, G,Rebaudi, A,Wang, HL. (2010). The effect of thread pattern upon implant osseointegration: Review. Clin Oral Implants Res. 21. 129
  • Steigenga, J,Al-Shammari, K,Misch, C,Nociti, FH,Wang H, L. (2004). Effects of Implant Thread Geometry on Percentage of Osseointegration and Resistance to Reverse Torque in the Tibia of Rabbits. J Periodontol. 75. 1233
  • Vivan Cardoso, M,Vandamme, K,Chaudhari, A,De Rycker, J,Van Meerbeek, B,Naert, I. (2015). Dental Implant Macro-Design Features Can Impact the Dynamics of Osseointegration. Clin Implant Dent Relat Res. 17. 639
  • Beutel, BG,Danna, NR,Granato, R,Bonfante, EA,Marin, C,Tovar, N. (2016). Implant design and its effects on osseointegration over time within cortical and trabecular bone. J Biomed Mater Res - Part B Appl Biomater. 104. 1091
  • Ivanoff, CJ,Sennerby, L,Lekholm, U. (1996). Influence of mono- and bicortical anchorage on the integration of titanium implants. A study in the rabbit tibia. Int J Oral Maxillofac Surg. 25. 229
  • Caneva, M,Lang, NP,Calvo Guirado, JL,Spriano, S,Iezzi, G,Botticelli, D. (2015). Bone healing at bicortically installed implants with different surface configurations. An experimental study in rabbits. Clin Oral Implants Res. 26. 293
  • Gehrke, SA,Pérez-Albacete Martínez, C,Piattelli, A,Shibli, JA,Markovic, A,Calvo Guirado, JL. (2017). The influence of three different apical implant designs at stability and osseointegration process: experimental study in rabbits. Clin Oral Implants Res. 28. 355
  • Kilkenny, C,Browne, WJ,Cuthill, IC,Emerson, M,Altman, DG. (2010). The ARRIVE Guidelines Checklist Animal Research : Reporting In Vivo Experiments. Br J Pharmacol. 8. 8-9
  • Soto-Peñaloza, D,Caneva, M,Viña-Almunia, J,Martín-de-Llano, JJ,Peñarrocha-Oltra, D,Peñarrocha-Diago, M. (2018). Bone-Healing Pattern on the Surface of Titanium Implants at Cortical and Marrow Compartments in Two Topographic Sites: an Experimental Study in Rabbits. Materials (Basel). 12. 85
  • Ernst, S,Stübinger, S,Schüpbach, P,Sidler, M,Klein, K,Ferguson, SJ. (2015). Comparison of two dental implant surface modifications on implants with same macrodesign: An experimental study in the pelvic sheep model. Clin Oral Implants Res. 26. 898-908
  • Gottlow, J,Barkamo, S,Sennerby, L. (2012). An Experimental Comparison of Two Different Clinically Used Implant Designs and Surfaces. Clin Implant Dent Relat Res. 14. 204
  • Rossi, F,Lang, NP,De Santis, E,Morelli, F,Favero, G,Botticelli, D. (2014). Bone-healing pattern at the surface of titanium implants: an experimental study in the dog. Clin Oral Implants Res. 25. 124
  • Lang, NP,Salvi, GE,Huynh-Ba, G,Ivanovski, S,Donos, N,Bosshardt, DD. (2011). Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans. Clin Oral Implants Res. 224. 349
  • Botticelli, D,Berglundh, T,Buser, D,Lindhe, J. (2003). Appositional bone formation in marginal defects at implants: An experimental study in the dog. Clin Oral Implants Res. 141. 1-9
  • Araújo, MG,Wennström, JL,Lindhe, J. (2006). Modeling of the buccal and lingual bone walls of fresh extraction sites following implant installation. Clin Oral Implants Res. 17. 606
  • Scala, A,Botticelli, D,Faeda, RS,Garcia Rangel, I,Américo de Oliveira, J,Lang, NP. (2012). Lack of influence of the Schneiderian membrane in forming new bone apical to implants simultaneously installed with sinus floor elevation: An experimental study in monkeys. Clin Oral Implants Res. 23. 175
  • Gomes, JB,Campos, FE,Marin, C,Teixeira, HS,Bonfante, EA,Suzuki, M. (2013). Implant Biomechanical Stability Variation at Early Implantation Times in Vivo: An Experimental Study in Dogs. Int J Oral Maxillofac Implants. 28. 128
  • Leonard, G,Coelho, P,Polyzois, I,Stassen, L,Claffey, N. (2009). A study of the bone healing kinetics of plateau versus screw root design titanium dental implants. Clin Oral Implants Res. 20. 232
Fuente de los datos: Dialnet