Effect of phenylephrine on static and dynamic accommodation

  1. Antonio J. del Águila Carrasco 1
  2. Francisco Lara 2
  3. Paula Bernal-Molina 3
  4. Resurrección Riquelme-Nicolás 2
  5. Iván Marín Franch 4
  6. José J. Esteve Taboada 1
  7. Robert Montés Micó 1
  8. Philip B. Kruger 5
  9. Norberto López Gil 1
  1. 1 Interuniversity laboratory for research in Vision and Optometry. Mixed group UVEG-UMU, Spain
  2. 2 Facultad de Óptica y Optometría, Universidad de Murcia
  3. 3 Department of Optics, and Optometry, and Vision Sciences. University of Valencia. Interuniversity laboratory for research in Vision and Optometry. Mixed group UVEG-UMU, Spain
  4. 4 Department of Optics, and Optometry, and Vision Sciences. University of Valencia; Interuniversity laboratory for research in Vision and Optometry. Mixed group UVEG-UMU,
  5. 5 State College of Optometry. State University of New York, USA
Show affiliations +
Journal:
Journal of Optometry: peer-reviewed Journal of the Spanish General Council of Optometry

ISSN: 1888-4296

Year of publication: 2019

Volume: 12

Issue: 1

Pages: 30-37

Type: Article

DOI: 10.1016/J.OPTOM.2018.01.005 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Journal of Optometry: peer-reviewed Journal of the Spanish General Council of Optometry

Abstract

We tested the hypothesis that changes in accommodation after instillation of Phenylephrine Hydrochloride (PHCl) observed in some studies could be caused by changes in optics. We performed two experiments to test the effects of PHCl on static and on dynamic accommodation in 8 and 6 subjects, respectively. Objective wavefront measurements were recorded of the static accommodation response to a stimulus at different distances or dynamic accommodation response to a sinusoidally moving stimulus (between 1 and 3 D of accommodative demand at 0.2 Hz). The responses were characterized using two methods: one that takes into account the mydriatic optical effects on the accommodation produced by higher-order aberrations of the eye and another that takes into account only power changes paraxially due to the action of the ciliary muscle and regardless of the pupil size. When mydriatic optical effects were taken into account, differences in responses before and after PHCl instillation were 0.51±0.53 D, and 0.12±0.15, for static and dynamic accommodation, respectively, and were statistically significant (p<0.039). When mydriatic optical effects were not taken into account, the differences in responses before and after PHCl instillation were −0.20±0.51 D, and −0.05±0.14, for static and dynamic accommodation, respectively, and were not statistically significant (p>0.313). The mydriatic effect of the PHCl causes optical changes in the eye that can reduce the objective and subjective measurement of accommodation.

Bibliographic References

  • Eyeson-Annan, M.L.,Hirst, L.W.,Battistutta, D.,Green, A. (1998). Comparative pupil dilation using phenylephrine alone or in combination with tropicamide. Ophthalmology.. 105. 726-732
  • Lovasik, J.V.,Kergoat, H. (1990). Time course of cycloplegia induced by a new phenylephrine-tropicamide combination drug. Optom Vis Sci.. 67. 352-358
  • Charman, W.N.,Whitefoot, H. (1977). Pupil Diameter and the Depth-of-field of the Human Eye as Measured by Laser Speckle. Opt Acta Int J Opt.. 24. 1211-1216
  • Wang, B.,Ciuffreda, K.J. (2006). Depth-of-Focus of the Human Eye: Theory and Clinical Implications. Surv Ophthalmol.. 51. 75-85
  • Campbell, M.C.W.,Harrison, E.M.,Simonet, P. (1990). Psychophysical measurement of the blur on the retina due to optical aberrations of the eye. Vision Res.. 30. 1587-1602
  • Liang, J.,Williams, D.R. (1997). Aberrations and retinal image quality of the normal human eye. JOSA A.. 14. 2873-2883
  • Alpern, M. (1958). Variability of Accommodation during Steady Fixation at Various Levels of Illuminance. JOSA.. 48. 193-197
  • Tucker, J.,Charman, W.N. (1986). Depth of focus and accommodation for sinusoidal gratings as a function of luminance. Am J Optom Physiol Opt.. 63. 58-70
  • Esteve-Taboada, J.J.,Del Águila-Carrasco, A.J.,Bernal-Molina, P.,Ferrer-Blasco, T.,López-Gil, N.,Montés-Micó, R. (2016). Effect of Phenylephrine on the Accommodative System. J Ophthalmol..
  • Biggs, R.D.,Alpern, M.,Bennett, D.R. (1959). The effect of sympathomimetic drugs upon the amplitude of accommodation. Am J Ophthalmol.. 48. 169-172
  • Garner, L.F.,Brown, B.,Baker, R.,Colgan, M. (1983). The effect of phenylephrine hydrochloride on the resting point of accommodation. Invest Ophthalmol Vis Sci.. 24. 393-395
  • Zetterström, C. (1984). The effect of phenylephrine on the accommodative process in man. Acta Ophthalmol.. 62. 872-878
  • Mordi, J.,Tucker, J.,Charman, W.N. (1986). Effects of 0.1% cyclopentolate or 10% phenylephrine on pupil diameter and accommodation. Ophthalmic Physiol Opt.. 6. 221-227
  • Gimpel, G.,Doughty, M.J.,Lyle, W.M. (1994). Large sample study of the effects of phenylephrine 2.5% eyedrops on the amplitude of accommodation in man. Ophthalmic Physiol Opt.. 14. 123-128
  • Sarkar, S.,Hasnat, A.M.,Bharadwaj, S.R. (2012). Revisiting the impact of phenylephrine hydrochloride on static and dynamic accommodation. Indian J Ophthalmol.. 60. 503-509
  • Culhane, H.M.,Winn, B.,Gilmartin, B. (1999). Human dynamic closed-loop accommodation augmented by sympathetic inhibition. Invest Ophthalmol Vis Sci.. 40. 1137-1143
  • Zetterström, C.,Hahnenberger, R. (1988). Pharmacological characterization of human ciliary muscle adrenoceptors in vitro. Exp Eye Res.. 46. 421-430
  • Tram, D.,Kasthurirangan, S.,Ostrin, L.,Glasser, A. (2002). The effects of phenylephrine on accommodation in humans. Optom Vis Sci.. 79. 174
  • Ostrin, L.A.,Glasser, A. (2004). The effects of phenylephrine on pupil diameter and accommodation in rhesus monkeys. Invest Ophthalmol Vis Sci.. 45. 215-221
  • Thibos, L.N.,Hong, X.,Bradley, A.,Applegate, R.A. (2004). Accuracy and precision of objective refraction from wavefront aberrations. J Vis.. 4. 329-351
  • López-Gil, N.,Fernández-Sánchez, V.,Thibos, L.N.,Montés-Micó, R. (2009). Objective Amplitude of Accommodation Computed from Optical Quality Metrics Applied to Wavefront Outcomes. J Optom.. 2. 223-234
  • López-Gil, N.,Fernández-Sánchez, V.,Legras, R.,Montés-Micó, R.,Lara, F.,Nguyen-Khoa, J.L. (2008). Accommodation-related changes in monochromatic aberrations of the human eye as a function of age. Invest Ophthalmol Vis Sci.. 49. 1736-1743
  • Del Águila-Carrasco, A.J.,Marín-Franch, I.,Bernal-Molina, P. (2017). Accommodation Responds to Optical Vergence and Not Defocus Blur Alone. Investig Opthalmology Vis Sci.. 58. 1758-1763
  • Lara, F.,Bernal-Molina, P.,Fernández-Sánchez, V.,López-Gil, N. (2014). Changes in the objective amplitude of accommodation with pupil size. Optom Vis Sci.. 91. 1215-1220
  • Tarrant, J.,Roorda, A.,Wildsoet, C.F. (2010). Determining the accommodative response from wavefront aberrations. J Vis.. 10. 4
  • Petersen, I.,Douglas, I.,Whitaker, H. (2016). Self controlled case series methods: an alternative to standard epidemiological study designs. BMJ. September. 354.
  • Atchison, D.A.,Collins, M.J.,Wildsoet, C.F.,Christensen, J.,Waterworth, M.D. (1995). Measurement of monochromatic ocular aberrations of human eyes as a function of accommodation by the Howland aberroscope technique. Vision Res.. 35. 313-323
  • Young, T. (1801). The Bakerian Lecture: on the mechanism of the eye. Philos Trans R Soc London.. 91. 23-88
  • López-Alcón, D.,Marín-Franch, I.,Fernández-Sánchez, V.,López-Gil, N. (2017). Optical factors influencing the amplitude of accommodation. Vision Res.. 141. 16-22
  • Bernal-Molina, P.,Castejón-Mochón, J.F.,Bradley, A.,López-Gil, N. (2015). Focus correction in an apodized system with spherical aberration. J Opt Soc Am A Opt Image Sci Vis.. 32. 1556-1563
  • Roorda, A.,Bobier, W.R. (1996). Geometrical technique to determine the influence of monochromatic aberrations on retinoscopy. J Opt Soc Am A Opt Image Sci Vis.. 13. 3-11
Data source: Dialnet