Perfil diurno de triglicéridos en sujetos con hiperlipidemia familiar combinada de una población del sur de Europa
- A. Bartual 1
- C. González 1
- S. Martínez-Hervás 1
- J.T. Real 1
- F.J. Chaves 1
- M.A. Priego 1
- J.F. Ascaso 1
- R. Carmena 1
- 1 Servicio de Endocrinología y Nutrición. Hospital Clínico Universitario de Valencia. Valencia. España
ISSN: 0214-9168, 1578-1879
Year of publication: 2005
Volume: 17
Issue: 1
Pages: 10-15
Type: Article
More publications in: Clínica e investigación en arteriosclerosis
Abstract
Objectives To compare postprandial lipidemia, evaluated by diurnal capillary triglyceride (cTG) profile measured with Accutrend GCT®, between control and familial combined hyperlipidemic (FCH) subjects from a Southern European population. Subjects and method 23 non related FCH subjects (13 women) and 45 non-diabetic normolipidemic controls (26 women) were studied. Anthropometric parameters, lipid profile, insulinemia and HOMA were measured in fasting state in all. In addition, TGc were determined by Accutrend GCT® for 3 days at 6 points: fasting, bedtime and before and 3 hours after dinner and lunch, respectively. Results FCH subjects showed significantly higher fasting insulinemia, HOMA values, TGc and area under the curve of TGc (AUCTGc) compared with controls. AUCTGc, as expression of postprandial lipidemia, correlated positively with obesity in all subjects. Conclusions FCH is a genetic model of postprandial hyperlipidemia. Obesity and abdominal fat deposits are positively related to postprandial lipidemia, probably due to insulin resistance.