Protocolo diagnóstico de sospecha de alteración del metabolismo férrico en el adulto
- Ortiz Polo, I.
- Paredes Arquiola, José María
- López Serrano, Antonio
- Moreno Osset, Eduardo
ISSN: 0304-5412
Year of publication: 2012
Issue Title: Enfermedades endocrinológicas y metabólicas: enfermedades del metabolismo lipídico, del hierro, cobre y otras metabolopatías
Series: 11
Issue: 19
Pages: 1177-1781
Type: Article
More publications in: Medicine: Programa de Formación Médica Continuada Acreditado
Abstract
Iron is an essential metal for life, but is toxic in large quantities. Disturbances of iron metabolism leading to overload, hereditary hemochromatosis highlighting and otherwise causes deficiency states, iron deficiency anemia being a global public health problem. Iron deficiency anemia may be due to excessive losses, increased iron needs or intestinal malabsorption. To arrive at the diagnosis, in addition to physical examination its necessary laboratory data, decrease in ferritin and transferrin saturation index (TSl) specific markers of iron deficiency. States of iron overload are induced by genetic and acquired diseases. Hemochromatosis is the most frequent genetic cause. Between acquired causes, chronic liver and blood diseases are relevant. The diagnosis often is complex, being necessary to carry both biochemical, genetic analysis or invasive testing.