Influences of haloperidol and sulpiride on social behavior of female mice in interactions with anosmic males

  1. Simón Pérez, Vicente M.
  2. Miñarro López, José
  3. Brain, Paul F.
  4. Redolat Iborra, Rosa
Revista:
Psicothema

ISSN: 0214-9915

Ano de publicación: 1991

Volume: 3

Número: 1

Páxinas: 79-85

Tipo: Artigo

DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Psicothema

Resumo

Influencias de Haloperidol y Sulpiride en el comportamiento social de ratón hembra en interacciones con machos anósmicos.- La mayoría de las investigaciones realizadas para estudiar los efectos de los fármacos sobre la conducta social y agonística en animales de laboratorio han utilizado sujetos macho. En este trabajo se evalúan los efectos del haloperidol y el sulpiride sobre la conducta social y defensiva de ratones hembra, utilizando para ello un método etofarmacológico que permite valorar el tiempo que los sujetos dedican a las diferentes categorías conductuales evaluadas. El resultado más destacado fué que la inmovilidad no aumentó significativamente en los animales tratados con haloperidol o sulpiride. La conducta exploratoria resultó afectada de modo diferente por los dos fármacos: El haloperidol disminuyó la investigación social mientras el sulpiride disminuyó la exploración no social. Los resultados se relacionan con estudios previos (realizados con sujetos macho en una situación experimental similar) que sugieren la existencia de posibles diferencias sexuales en los efectos conductuales de estos fármacos.

Referencias bibliográficas

  • Bartholini, G. (1976). Differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic systems. Journal of Pharmacy and Pharmacology. 28, 429-433.
  • Bartholini, G. and Lloyd, K. G. (1980). Bio­chemical effects of neuroleptic drugs. In: F. Hoffmeister & G. Stille (eds.). Psycho­tropic Agents. Part I: Antipsychotics and Antidepressants (pp. 193-212). Berlin, Springer-Verlag.
  • Benton, D., Smoothy, R., and Brain, P. F. (1985). Comparison of the influence of morphine sulphate, morphine -3- glucuro­nide and tifluadom on social encounters in mice. Physiology and Behavior, 35, 689-693.
  • Brain, P. F. and Al-Maliki, S. (1978). A com­parison of "intermale" fighting in 'standard opponent' tests and attack directed to­ wards locusts by "TO" strain rnice: effects of simple experimental manipulations. Animal Behaviour, 26, 723-737.
  • Brain, P. F., Smoothy, R., Benton, D.(1985). An ethological analysis of the effects of tifluadom on social encounters in male al­bino mice. Pharmacology , Biochemistry and Behavior, 23, 979-985
  • Brain, P. F., McAllister, K.H., and Walms­ ley, S. V. (1989). Drug effects on social behaviour: Methods in ethopharmacolo­gy. In: A. A. Boulten, G. B. Baker and A.J. Greenshaw (eds.) "Neuromethods, Vol­ume 13 Psychopharmacology", (pp. 687- 739). Clifton, New Jersey. The Human Press Inc.
  • Dalton, J.C.H.; Vickers, G.J. and Roberts, D.C.S. (1986). lncreased self-administration of cocaine following haloperidol sex­ dependent effects of the antiestrogen ta­moxifen. Pharmacology, Biochemistry and Behavior. 25, 497-501.
  • Hyttel, J. and Amt, J. (1986). Characteriza­tion of dopamine D-1 and D-2 receptors. In: G. R. Breese & l. Creese (eds.). "Neuro­biology of central receptors ", (pp. 15- 28). New York, Plenum Press.
  • Jenner, P., Clow, A., Reavill, C., Theodorov, A & Mardsen, C.D. (1978). A behavioral and biochemical comparison of DA recep­tor blockage produced by haloperidol with that produced by substituted benzamide drugs. Life Sciences, 23, 545-549.
  • Jenner, P. and Marsden, C.D. (1979). The sub­stituted benzamides - a novel class of dop­amine antagonists. Life Sciences, 25, 479-486.
  • Kebabian, J.W. and Calne, D.B. (1979). Mul­tiple receptors for dopamine. Nature, 277, 93-96.
  • Martínez, M. Castaño, D. Simón, V. Brain, P.P. (1986). An ethopharmacological as­sessment of the influence of cyproterone acetate on social interaction in male mice. IRCS Medica/ Science, 14, 44-45.
  • Martínez, M. Miñarro, J. y Simón, V. M. (1991). Análisis Etoexperimental de la conducta agonística en ratones. Psicoló­gica, -in press-.
  • Miñarro, J. Brain, P. F. and Simón, V. (1989). "Sex differences in the effects of haloperi­dol on aggressive behavior in mice" 8th. Biennal World Meeting I.S.R.A., Abstract in Aggressive Behavior, vol. 15 (1), 90-91.
  • Miñarro, J. Castaño, D. Brain, P. F. and Si­món, V.M. (1990). Haloperidol does not antagonize the effects of stress on aggres­sive behaviour in mice. Physiology and Behavior, 47, 281-285.
  • Olivier, B., Van Aken, H., Jaarsma, l., Van Oorschot, R., Zethof, T. and Bradford, D. (1984). Behavioural effects of psychoactive drugs on agonistic behaviour in male territorial rats (resident-intruder model). In: K. A. Miczek, M. R. Kruk, and B. Oliv­ ier (eds.). "Ethopharmacological Aggres­sion Research ". (pp. 137-156). New York, Alan R. Liss.
  • Poshivalov, V. P. (1982). Ethological analy­sis of neuropeptides and psychotropic drugs: effects on intraspecies aggression and sociability of isolated mice. Aggressive Behavior, 8, 355-369.
  • Redolat, R. Brain, P. F. and Simón, V.M. (-in press-). Sulpiride has an antiaggressive ef­fect in mice without markedly depressing motor activity. Neuropharmacology.
  • Simón, V., Miñarro, J., Redolat, R., and Gar­mendia, L (1989) An ethopharmacological study of the effects of three neuroleptics (haloperidol, clozapine and sulpiride) on aggressive encounters in male mice. In: R.J. Blanchard, P.F. Brain, D. C. Blan­ chard and S. Parmigiani (eds.) "Ethoexpe­rimental Approaches to the Study of Be­havior" (pp. 474-483). Dordrezht, Kluwer Academic Publishers.
  • Smoothy, R., Brain, P. F. Berry, M. S. and Haug, M. (1986). Alcohol and social behaviour in group-housed female mice. Physiology and Behavior. 3 7, 689-694.
  • Swet, C. J. (1975): Drug-induced dystonia. American Journal of Psychiatry, 132, 532-534.
Fonte de datos: Dialnet