Diferencias de genero en los efectos del haloperidol y otros neurolépticos

  1. Parra Guerrero, Andrés
  2. Arenas Fenollar, María Carmen
  3. Simón Pérez, Vicente M.
Revista:
Psicothema

ISSN: 0214-9915

Año de publicación: 1995

Volumen: 7

Número: 2

Páginas: 327-338

Tipo: Artículo

DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Psicothema

Resumen

Se revisa la literatura reciente sobre las diferencias de género en el efecto de los neurolépticos, especialmente el haloperidol. Los datos procedentes, tanto de estudios clínicos como de la experimentación animal, demuestran que algunos efectos de los antipsicóticos, especialmente del haloperidol, son sexualmente dimórficos. Las mujeres esquizofrénicas premenopaúsicas manifiestan una mejor respuesta terapéutica que los hombres al tratamiento con neurolépticos y tras la menopausia tienden a presentar más efectos extrapiramidales que los varones. Los estudios experimentales con animales presentan resultados contradictorios: apareciendo los machos o las hembras como los más afectados dependiendo del tipo concreto de conducta considerada. Sobre los posibles mecanismos de estas diferencias de género en la respuesta a los neurolépticos se señala el supuesto papel protector de los estrógenos sobre el sistema dopaminérgico, aunque el mecanismo molecular implicado todavía no ha sido descrito.

Referencias bibliográficas

  • Arenas, M. C., Parra, A. y Simón, V. M. (1993). Gender differences in escape -avoidance behavior of mice after haloperidol administration. Pharmacology Biochemistry & Behavior, 44: 233-236.
  • Arenas, M. C., Parra, A. y Simón, V. M. (en prensa). Gender differences in the effects of haloperidol on avoidance conditioning in mice. Pharmacology Biochemistry & Behavior.
  • Ayd, F. J. Jr. y Baltimore, M. D. (1961). A survey of drug-induced extrapyramidal reactions. Journal of American Medical Association, 175: 1054-1060.
  • Baptista, T., Parada, M. y Hernandez, L. (1987). Long term administration of some antipsicotic drugs increases body weight and feeding in rats. Are D2 dopamine receptors involved? Pharmacology Biochemistry & Behavior, 27: 399-405.
  • Beninger, R. J. (1989). Dissociating the effects of altered dopaminergic function on performance and learning. Brain Research Bulletin, 23: 365-371.
  • Campbell, A., Baldessarini, R. J. y Cremens, M. C. (1988). Dose-catalepsy response to haloperidol in rat: effects of strain and sex. Neuropharmacology, 27: 1197-1199.
  • Carlton, E L. (1983). A primer of behavioral pharmacology. Concepts and principies in the behavioral analysis of drug action. W. H. New York-San Francisco: Freeman and Company.
  • Castle, D. J. y Murray. R. M. (1991). The neurodevelopmental basis of sex differences in schizophrenia. Psychological Medicine, 21: 565--575.
  • Dalton, J. C. H., Vickers, G. J. y Roberts, D. C. S. (1986). Increased self-administration of cocaine following haloperidol: sex-dependent effects of the antiestrogen tamoxifen. Pharmacology Biochemistry & Behavior, 25: 497-501.
  • Dawkins, K. y Potter, W. Z. (1991). Gender differences in pharmacokinetics and pharmacodynamics of psychotropics: focus on women. Psychopharrnacology Bulletin, 27: 417-426.
  • Dawkins, K., Rudorfer, M. V. y Potter, W.Z. (1993). Comments on gender differences in pharmacokinetics and pharmacodynamics. The American Journal of Psychiatry, 150: 678-679.
  • De La Cruz, F., Pellis, S. M. y Pellis, V. C. (1987). Sex differences in the effects of haloperidol, morphine and their combination on colonic temperature in rats. Experimental Neurology, 96: 376-380.
  • Faraone, S. V., Chen, V. J., Goldstein, J. M. y Tsuang, M. T. (1994). Gender differences in age at onset of schizophrenia. British Journal of Psychiatry, 164: 625-629.
  • Fernández-Ruiz, J. J., De-Miguel, R., Hernández, M. L. y Ramos, J. A. (1990). Timecourse of the effects of ovarian steroids on the activity of limbic and striatal dopaminergic neurons in female rat brain. Pharmacology Biochemistry & Behavior, 36: 603-606.
  • Goldberg, S.C., Schooler, N. R., Davidson, E. M. y Kayce, M. M. (1966). Sex and race differences in response to drug treatment amone schizophrenics. Psychopharmacologia (Berl.), 9:31-47.
  • Häfner, H., Behrens, S., De Vry, J y Gatas, W. F. (1991). An animal model for the effects of estradiol on dopamine-mediated behavior: implications for sex differences in schizophrenia. Psychiatry Research, 38: 125-134.
  • Halbreich, U., Asnis, G., Goldstein, S., Nathan, R. S., Zander, K. y Herne, J. V (1984). Sex differences in response to psychopharmacological interventions in humans. Psychopharmacology Bulletin, 20:526-530.
  • Harrer, S. y Schmidt, W. J. (1986). Oestrogen modulates dopamine-controlled behaviours in the male ferret. European Journal of Pharmacology. 128:129-132.
  • Hruska, R.E. y Silbergeld, E. K. (1980). Increased dopamine receptor sensitivity after estrogen treatment using the rat rotation model. Science, 208: 1466-1468.
  • Kazandjian, A., Spyraki, C., Papadopoulou, Z., Sfikakis, A. y Varonos, D. D. (1988). Behavioural and biochemical effects of haloperidol during the oestrous cycle of the rat. Neuropharmacology, 27: 73-78.
  • Lehr, E. (1980). Testing antipsychotic drug effects with operant behavioral techniques. En F. Hoffmeister y G. Stille (Eds.) Psychotropic agents. Part I.: Antipsychotics and antidepressants. Berlin: Springer-Verlaig.
  • Miller, L. G., Jankovic, J. (1990). Neurologic approach to drug-induced movement disorders: a studv of 125 patients. South Medical Journal, 83: 525-532.
  • Navarro, J. E, Vera, E., Puigcerver, A. y MartinLopez, M. (1993). Gender differences in catalepsy of mice after haloperidol administration. Medical Science Research, 21: 815-816.
  • Palermo-Neto, J. y Dorce, V. A. C. (1990). Influences of estrogen and/or progesterone on some dopamine related behavior in rats. General Pharmacology, 21: 83-87.
  • Rance, N., Wise, P. M., Selmanoff, M. K. y Barraclough, C. A. (1981). Catecholamine turnover rates in discrete hypothalamic areas and associated changes in median eminence luteinizing hormone-releasing hormone and serum gonadotropins on proestrus and diestrous day 1. Endocrinology, 108:1795-1802.
  • Roberts, D. C. S., Dalton, J. C. H. y Vickers, G. J. (1987). Increased self-administration of cocaine following haloperidol: Effect of ovariectomy, estrogen replacement and estrous cyele. Pharmacology Biochemistry & Behavior, 26: 37-43.
  • Rupniak, N. M. J., Mann, S., Hall, M. D., Fleminger, S., Kilpatrick, G., Jenner, P. y Marsden. C. D. (1986). Differential alterations in striatal acetylcholine function in rats during 12 months' continuous administration of haloperidol, sulpiride or clozapine. Clinical Neuropharmacology, 9: 282-292.
  • Seeman, M. V. (1986). Current outcome in schizophrenia: women vs men. Acta Psychiatrica Scandinavica, 73: 609-617.
  • Smith, J. M., Oswald, W. T., Kucharski, L. T. y Waterman, L. J. (1978). Tardive Dyskinesia: age and sex differences in hospitalized schizophrenics. Psychopharmacology, 58: 207-211.
  • Swett, C. Jr. (1975). Drug-induced dystonia. American Journal of Psychiatry, 132: 532-534.
  • Tonnaer, J. A.D. M., Leinders, T. y Van Delft, A. M. L. (1989). Ovariectomy and subchronic estradiol-17β administration decrease dopamine D1 and D2 receptors in rat striatum. Psychoneuroendocrinology. 14: 469-476.
  • Van Hest, A., Van Haaren, E. y Van de Poll, N. E. (1988). Haloperidol, but not apomorphine, differentially affects low response rates of male and female wistar rats. Pharmacology Biochemistry & Behavior, 29: 529-532.
  • Wysowski, D. K. y Baum, C. (1989). Antipsychotic drug use in the United States, 1976-1985. Archives of General Psychitry, 46: 929-932.
  • Yonkers, K. A., Kando, J. C., Cole, J. O. y Blumenthal, S. (1992). Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication. The American Journal of Psychiatry, 149: 587-595.
Fuente de los datos: Dialnet