Asociaciones de la concentración de adiponectina sérica con parámetros antropométricos, bioquímicos y presión arterial en población de alto riesgo cardiovascular
- Carolina Ortega-Azorín 1
- Paula Carrasco 1
- Francesc Francés 1
- Marisa Guillén 1
- José Vicente Sorlí 1
- José Ignacio González 1
- Carmen Sáiz 1
- Vicente Pascual 2
- Elena Godoy-Gijón 1
- Dolores Corella 1
- 1 Departamento de Medicina Preventiva y Salud Pública. Universidad de Valencia. Valencia
- 2 Centro de Salud Gran Vía. Castellón. Castellón
ISSN: 0214-9168, 1578-1879
Year of publication: 2007
Volume: 19
Issue: 4
Pages: 174-180
Type: Article
More publications in: Clínica e investigación en arteriosclerosis
Abstract
Introduction Serum adiponectin concentrations have been inversely associated with abdominal obesity, a more favorable lipid profile, and less insulin resistance. Nevertheless, recent studies in the population at high cardiovascular risk, especially that with altered renal function, show that high adiponectin concentrations are an unfavorable indicator. The aim of this study was to analyze the association of adiponectinemia with anthropometric, biochemical and blood pressure parameters in patients with high cardiovascular risk. Patients and methods We studied 185 patients (133 women and 52 men), participating in the PREDIMED study (mean age 65.5 ± 4.3 years). Clinical, anthropometric, biochemical and blood pressure data, as well as adiponectinemia, were analyzed. Results The body mass index was slightly higher in women than in men (31.1 ± 4.3 kg/m2 versus 29.4 ± 4.0 kg/m2; p = 0.01). The prevalence of diabetes was 42.2% and was higher in men (61.5%) than in women (34.6%). Adiponectin concentrations were higher in women than in men (11.0 ± 5.2 versus 6.9 ± 3.3 μg/mL; p < 0.001). After adjustment for sex, mean adiponectin concentrations were higher in nondiabetic than in diabetic participants (10.3 ± 0.5 versus 7.5 ± 0.5; p < 0.001). Positive correlations between adiponectin and high-density lipoprotein cholesterol were obtained (r = 0.36; p < 0.001). Negative correlations with plasma triglycerides (r = −0.28; p < 0.001), glycemia (r = −0,28; p < 0.001) and plasma creatinine (r = −0.28; p = 0.007) were found. No association was found between adiponectinemia and systolic or diastolic blood pressure. Conclusions In the population studied with high cardiovascular risk, the correlations between adiponectinemia and anthropometric parameters and blood pressure were less clear than those in the general population. However, adiponectin concentrations were lower in diabetics and were inversely correlated with creatinine levels.