Papel de la eminencia talámica, el sistema olfativo principal y el sistema olfativo accesorio en la maduración sexual del encéfalo y las manifestaciones clínico-morfológicas del síndrome de Kallmann
- Leandro Castañeyra-Ruiz 2
- Nélida Rancel-Torres 2
- María Castañeyra-Ruiz 3
- Juan M. González-Toledo 2
- Marina Gutiérrez-Vilar 2
- Julio A. Hernández-García 2
- Patricia Hernández-Gutiérrez 2
- Clara Blasco-Igual 4
- Francisco J. Pérez-Moltó 1
- Ibrahim González-Marrero 2
- 1 Departamento de Anatomía y Embriología Humana, Universidad de Valencia. España
- 2 Departamento de Ciencias Médicas Básicas, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife. Islas Canarias. España
- 3 Departamento de Prehistoria, Arqueología, Antropología e Historia Antigua. Universidad de La Laguna. Tenerife. Islas Canarias. España
- 4 Departamento de Fisioterapia, Universidad de Valencia. España
ISSN: 1697-5529
Argitalpen urtea: 2014
Zenbakia: 10
Orrialdeak: 37-44
Mota: Artikulua
Beste argitalpen batzuk: Majorensis: Revista Electrónica de Ciencia y Tecnología
Laburpena
The olfactory system development and brain sexual maturation, in man and animals, are closely related. Currently the overlap between the formation of the olfactory system and the migration of neurons that synthesize gonadotropin-releasing hormone (GnRF) are described. The GnRF neurons migrate from the medial portion of the nasal epithelium through the olfactory nerves and the main olfactory bulb to the anterior hypothalamus. Furthermore, Kallmann syndrome (KS) is a genetic disorder in which combines hypogonadotropic hypogonadism and anosmia. Hypogonadism is characterized by the absence or reduced levels of gonadotropin-releasing hormone and anosmia is due to aplasia of the olfactory bulb. The basic clinical manifestations of KS are: anosmia and the absence of puberty. The structures responsible for the maturation of the main and accessory olfactory systems, the sexual differentiation of the brain and its relationship with all the clinical manifestations of Kallmann syndrome are analyzed in this review.